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| Name | Class |
|---|---|
| Cantonal Hospital of St. Gallen | OTHER |
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Human leptospirosis is a zoonotic disease caused by bacteria of the genus Leptospira. Due to its frequent inapparent course or mild severity with unspecific symptoms and limited availability of diagnostic laboratories the incidence of leptospirosis is likely to be underestimated. The hospital of Val Müstair is the major healthcare provider of a rural mountain valley in the canton of Graubünden/ Switzerland with approximately 1500 inhabitants. A relevant prevalence of Leptospira spp. antibodies in the population of the Val Müstair due to its geographic and social risk profile for Leptospira infection, namely the close contact of the population to both livestock and wildlife in agriculture and hunting is estimated. The aim of this study is to analyze the burden of this disease in order to evaluate the need of preventive measures. In addition, seroepidemiological data for the Hepatitis E virus (HEV) and for tularemia will be collected.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample collection | Other | Blood sample collection (at baseline and approximately two years after baseline). Enzyme-linked immunosorbent assays will be used to screen for IgG and IgM antibodies directed against the three pathogens (Leptospirosis, Tularemia, Hepatitis E). | ||
| Data collection | Other | Data collection on sociodemographic questions e.g. profession, leisure activities, animal contact |
| Measure | Description | Time Frame |
|---|---|---|
| Change in presence of antibodies against Leptospira spp, Francisella tularensis and Hepatitis E | Change in presence of antibodies against Leptospira spp, Francisella tularensis and Hepatitis E evaluated by serology at two different time points | at baseline and approximately two years after baseline (project duration for each patient is one day or two days respectively, if they agree for another blood sampling in two years) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in presence of antibodies in risk populations (hunters and farmers) | Change in presence of antibodies against Leptospira spp., Hepatitis E and Francisella tularensis and of all pathogens in risk populations (hunters and farmers) | at baseline and approximately two years after baseline (project duration for each patient is one day or two days respectively, if they agree for another blood sampling in two years) |
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Inclusion Criteria:
Exclusion Criteria:
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250 participants presenting to the medical office of the Hospital of Val Müstair will be included. There will be a consecutive ongoing recruitment through the medical staff in daily clinical practice and during regular blood donation days. Risk populations (hunters and farmes, national park rangers) will be directly addressed (newspaper announcement and via associations).
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| Name | Affiliation | Role |
|---|---|---|
| Michael Osthoff, PD Dr. med. | University Hospital Basel, Division of Internal Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel, Division of Internal Medicine | Basel | 4031 | Switzerland | |||
| Center da sanda Val Muestair |
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| ID | Term |
|---|---|
| D007922 | Leptospirosis |
| D016751 | Hepatitis E |
| D014406 | Tularemia |
| ID | Term |
|---|---|
| D013145 | Spirochaetales Infections |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
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| ID | Term |
|---|---|
| D003625 | Data Collection |
| ID | Term |
|---|---|
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
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Blood samples will be stored at -20°C in a dedicated freezer, situated at the Hospital of Val Müstair and will be transferred to a dedicated at -80°C with limited access at the University Hospital Basel after recruitment is complete. If appropriate consent is granted, the samples not used in the study will be biobanked and may be used in future studies.
| Val Müstair |
| 7536 |
| Switzerland |
| D007239 | Infections |
| D006525 | Hepatitis, Viral, Human |
| D014777 | Virus Diseases |
| D012327 | RNA Virus Infections |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D017282 | Tick-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |