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| Name | Class |
|---|---|
| University Ghent | OTHER |
| Bill and Melinda Gates Foundation | OTHER |
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Maternal undernutrition concerns 10-19% of women of reproductive age globally, the vast majority of which live in sub Saharan Africa and south Asia. Recommendations for nutritional interventions to tackle the problem range from per-pregnancy supplementation to upstream interventions targeting women of reproductive age before conception. To render the latter interventions cost-effective and sustainable, experts recommend to focus on food processing that leads to an enhanced nutrient content. One such method, which has been known and practiced for centuries in diverse societies, is fermentation. Traditionally fermented foods are diverse, widespread and highly appreciated in Burkina Faso. The present study aims to investigate the effect of fermented millet porridge on gut microbiota diversity, stool short chain fatty acid concentration and inflammation markers level in women of reproductive age living in rural Burkina Faso.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fermented porridge | Experimental | this study arm participant will consume fermented millet porridge, daily |
|
| Non-fermented porridge | Active Comparator | this study arm participants will consume non-fermented millet porridge, daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fermented porridge | Other | A millet porridge (fermented or not, depending on group allocation) serving will be provided to participants daily, for consumption. consumption will be directly observed. |
| Measure | Description | Time Frame |
|---|---|---|
| Gut microbiota diversity | gut microbiota alpha and beta diversity | 0 to 13 weeks |
| Concentration of inflammation markers in blood and stool | Concentration of IL1-beta, IL 8, IL 6, IL 33, TNF-alpha, lipocalin 2, myeloperoxidase, calprotectin | 0 to 13 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of short chain fatty acid in stool | Concentration of C2-C8 fatty acids in stool | 0 to 13 weeks |
| concentration of macronutrients in millet dough and porridge | Levels of carbohydrates, lipids, protein, dietary fiber and phytates |
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Inclusion Criteria:
Participant are
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laeticia C TOE, MD | Contact | 0022671007272 | cellaety@yahoo.fr | |
| Lionel O Ouedraogo | Contact | 0022670530583 | lionel.olivier.ouedraogo@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Laeticia C TOE | IRSS-DRO | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRSS-DRO | Recruiting | Bobo-Dioulasso | Houet, Région Des hauts-Bassins | 01 BP 545 | Burkina Faso |
Data sharing plans will be done according to the BMGF policy
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 2 to 8 weeks |
| relative abundance of bacterial and fugal micro-organisms in millet dough and porridge | Count of microbial populations | 2 to 8 weeks |
| Concentration of Ferritin in plasma | Ferritin levels in Plasma | 0- to 13 weeks |
| Number of participant with anemia | hemoglobin concentration in grams per deciliter | 0 to 13 weeks |