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The purpose of this study is to compare the feasibility and accuracy of two methods of non-invasive hemodynamic assessments - bioreactance as assessed by non-invasive cardiac output monitoring (NICOM; Cheetah Medical) and pulse wave analysis as assessed by finger cuff arterial pressure (ClearSite, Edwards Life Sciences) - compared to hemodynamic assessments by intermittent echocardiography in early onset preeclampsia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heart and vascular function | All study participants will have echocardiography and non-invasive monitoring by chest/back sensors and a finger cuff to determine the best method of monitoring heart and vascular function in preeclampsia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiogrpahy and non-invasive monitoring | Diagnostic Test | Study participants will have echocardiography and non-invasive monitoring by chest/back sensors and a finger cuff. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiac output (L/min) as measured by NICOM (bioreactance) monitoring | Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia | Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
| Change in systemic vascular resistance (dynes/sec*cm-5) as measured by NICOM (bioreactance) monitoring | Systemic vascular resistance ranges 600-2000 dynes/sec*cm-5, higher values associated with more severe preeclampsia | Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
| Change in Cardiac output (L/min) as measured by Clearsite (pulse wave analysis) monitoring | Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia | Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
| Change in Systemic vascular resistance (dynes/sec*cm-5) as measured by Clearsite (pulse wave analysis) monitoring | Systemic vascular resistance ranges 600-2000 dynes/sec*cm-5, higher values associated with more severe preeclampsiaanalysis) monitoring | Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
| Change in Cardiac output (L/min) as measured by transthoracic echocardiography | Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia | Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with severe preeclampsia.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale University Hospital | New Haven | Connecticut | 06510 | United States |
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| Change in Systemic vascular resistance (dynes/sec*cm-5) as measured by transthoracic echocardiography |
Systemic vascular resistance ranges 600-2000 dynes/sec*cm-5, higher values associated with more severe preeclampsia |
| Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum) |
| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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