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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2022-02382 | Registry Identifier | CTRP (Clinical Trials Reporting Program) |
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The purpose of this study is to determine the prevalence of genetic mutations that increase the risk of cancer and other medically actionable diseases in kidney transplant patients and to assess the impact of genetic testing on subsequent surveillance for cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kidney Transplants | Kidney transplant patients who are within one-year post transplant. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genetic Health Screen Panel | Diagnostic Test | This panel covers cardiomyopathy genes, and cancer genes. The results of this panel are reported as Positive (pathogenic or likely pathogenic mutation identified in one or more genes) or Negative (no pathogenic/likely pathogenic mutations identified). |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic mutations of cancer | Number of subjects to have genetic mutations of cancer in kidney transplant patients receiving care at Mayo Clinic Arizona | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The impact of genetic testing | Current guidelines for cancer screening have limitations, as its mostly age based. Immunosuppression can lead to a increased risk of cancer in the kidney transplant population. By utilizing a multi gene panel we'll look for the number subjects with positive findings and see how recommendations of care change vs standard of care as recommended by the National Comprehensive Cancer Network (NCCN). Genetic testing and family history may change the practice regarding cancer screening in subjects undergoing kidney transplant evaluation. |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic mutations of cardiomyopathy | Prevalence of genetic mutations for cardiomyopathies in kidney transplant recipients | 1 year |
Inclusion Criteria:
- Post transplant Kidney and Kidney Pancreas recipients.
Exclusion Criteria:
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Participants will be identified internally to Mayo Clinic Arizona via the kidney transplant program within one-year post transplant.
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| Name | Affiliation | Role |
|---|---|---|
| Girish Mour, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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Participants will be asked to provide a blood sample. Participants may be asked to provide an additional research blood sample for biobanking purposes, up to 40mL of blood per subject .
|
| 1 year |
| Develop a Biorepository | Create a biorepository based on whole exome sequencing and clinical data for future analysis | 1 year |