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A Randomized Controlled Clinical Trials was conducted to study the medium-long term impact of a complementary weaning using adult foods typical of Mediterranean Diets (MD) on children taste development and eating habits, and on the microbiota composition.
Main objectives were to assess the effect of such weaning scheme on:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mediterranean Diet group | Experimental |
| |
| Control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mediterranean Diet weaning scheme | Dietary Supplement | Kids in experimental group were weaned by using fresh foods traditionally used in MD and appropriately adapted to infants including seasonal fruit and vegetables, various kinds of fresh blue fish, spices and herbs. No salt was used while a small amount of Parmesan cheese was added. No sugar was added to any meal. |
| Measure | Description | Time Frame |
|---|---|---|
| Proportions of children showing a good adherence (i.e. KidMed score >= 8) to Mediterranean diet | KidMed is a questionnaire measuring Mediterranean Diet Quality for children and adolescents. The final score ranges from from 0 to 12 where scores >=8 indicates optimal Mediterranean diet; score within range 4-7 suggest that an improvement is needed to adjust intake to Mediterranean patterns and score <=3 indicate very low diet quality. | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Average of the KidMed score | 36 months | |
| Average children's BMI | 36 months | |
| Proportion of overweight and obese children |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41374011 | Derived | de Franchis R, Bozza L, Cortese P, D'Antonio L, D'Avino A, Gasparini N, Ippolito G, Spadaro R, Tedesco M, Antignani A, De Filippis F, Valentino V, Auricchio R, Auricchio S, Bruzzese D. Can Early Nutrition Be Responsible for Future Gut Microbiota Changes and Different Health Outcomes? Nutrients. 2025 Nov 27;17(23):3721. doi: 10.3390/nu17233721. |
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|
Overweight and obesity were defined according to extra-centiles of the Italian BMI growth norms published in Cacciari et al. 2006. |
| 36 months |
| Variation of microbial communities between arms based on Bray-Curtis dissimilarity | Bray-Curtis dissimilarity estimates difference in microbial abundances between two samples. It ranges from 0 to 1. The greater the index value the larger the difference in species abundances between groups. | 48 months |