Evaluation of the Possible Effect of Inspiratory Muscle Training on Inflammation Markers and Oxidative Stress in Childhood Asthma

Evaluation of the Possible Effect of Inspiratory Muscle Training on Inflammation Markers and Oxidative Stress in Childhood Asthma

As inflammation and oxidative stress increase in asthma patients, the severity of symptoms and clinical findings increase. Therefore, this study was planned to evaluate the possible effect of inspiratory muscle training (IMT) on inflammation markers and oxidative stress in childhood asthma.

The study included asthma patient; 35 routine medication, 35 drug therapy and inspiratory muscle training (IMT), and 35 healthy total 105 children aged 8-17 years. Demographic information and hemogram values were recorded. Functional capacity was evaluated with the 6-minute walking test, quality of life PedsQL, respiratory muscle strength oral pressure measuring device, respiratory function test, dyspnea severity with Modified Borg Scale. C-Reactive Protein (CRP), Periostin, Transforming Growth Factor-βeta (TGF-β), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) were analyzed. IMT was given with a Threshold IMT device for 7 days/6 weeks at 30% of maximal inspiratory pressure, and then a second evaluation was made.

Inclusion Criteria:

• Have been diagnosed with asthma,
• Between the ages of 8-17,
• No asthma attack,
• Cooperating with the study,
• Without cerebral palsy, mental retardation or any other major neurological diagnosis,
• Agreeing to participate in the study,
• Cases whose medication has not been changed for at least three weeks.

Exclusion Criteria:

• Presence of kyphoscoliosis that may affect respiration,
• Having advanced postural alignment problem,
• Having mental problems,
• Having neuromuscular disease,
• Making changes in the medications used in the last three weeks,
• Presence of inflammatory diseases such as juvenile idiopathic arthritis.