The purpose of this study is to measure the amount of the antibiotic, tebipenem (SPR994) that is bioavailable after crushing the tablet and administering through a feeding tube with and without tube feeds.

This study will enroll 12 healthy volunteers and will take place in the Clinical Research Center at Hartford Hospital. Each volunteer will receive 2 doses (~22h washout period between doses) and will be randomly assigned to three treatment groups:

1) intact tebipenem 600mg dose (2 300mg tablets) taken orally; 2) a crushed tebipenem 600mg dose (2 300mg tablets) suspended in water and administered via the NGT; 3) a crushed tebipenem 600mg dose (2 300mg tablets) suspended in water and administered via a nasogastric tube with concurrent enteral tube feeds (run for 2h before dose and 4h post-dose). Crushed tablets will be administered by syringe through the nasogastric tube. An additional 150ml of water will be used to rinse out any remaining drug in syringe and administered to the volunteers to ensure delivery of the entire dose.

Inclusion Criteria:

1. Willing to participate in the trial, give written informed consent, and comply with the trial restrictions.
2. Gender: male or female with a negative serum pregnancy test (β-human chorionic gonadotropin) at Screening and Day -1; females may be of childbearing potential or of non-childbearing potential.
3. Age >= 18 years at screening

Exclusion Criteria:

1. Female who is pregnant, lactating, or at risk of becoming pregnant during this trial.
2. History of hypersensitivity or allergy to tebipenem or its derivatives and any β-lactam antibiotic.
3. History of hypersensitivity to lidocaine or lidocaine derivatives.
4. Concurrently receiving sodium valproic acid or valproate derivatives.
5. Concurrently receiving probenecid.
6. Body Mass Index (BMI) ≥ 35 kg/m2
7. Creatinine clearance (CrCl) < 50ml/min, as calculated by Cockcroft-Gault using ideal body weight
8. Presence of anemia, thrombocytopenia, or leukopenia as defined by hematocrit, platelet, or white blood cell count < 75% of the lower limit of normal
9. Aspartate transaminase, alanine aminotransferase, or alkaline phosphatase greater than five times upper limit of normal.
10. Total bilirubin greater than three times the upper limit of normal.
11. Any known active co-morbidity listed on medical history i.e., seizures or that becomes apparent during physical examination.
12. Positive urine drug screen (cocaine, Tetrahydrocannabinol, opiates, benzodiazepines, and amphetamines).
13. History of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for men (1 drink = 5 ounces of wine or 12 ounces of beer or 1.5 ounces of hard liquor) within 6 months of screening.
14. Use of tobacco- or nicotine-containing products in excess of the equivalence of 5 cigarettes per day.
15. Consumption of caffeine within 3 days of the study.
16. Use of prescription or nonprescription drugs, vitamins, or dietary supplements within 7 days or 5 half-lives, whichever is longer (with the exception of acetaminophen at doses of ≤ 1 g/day). The use of hormonal methods of contraception (including oral and transdermal contraceptives, injectable progesterone, progestin subdermal implants, progesterone-releasing intrauterine devices, post-coital contraceptive methods) is permitted.
17. Males who are not surgically sterilized (with female partners of childbearing potential) and females of childbearing potential who do not agree to use two highly effective methods of contraception from screening, during this trial, and for 90 days after the last dose of study drug.
18. History or current presence of nasal structural abnormalities including a broken nose or deviated septum.
19. Employee of the Center for Anti-Infective Research and Development, Clinical Research Center, or the Sponsor.
20. Any other documented reason felt by the investigator to potentially affect the outcomes of the study.