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Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms. Within the parotid gland there are branches of the intra-parotid facial nerves, which are tiny in calibre and are prone to injury to injury during operation. It has been reported in recent retrospective view that the incidence of temporary and permanent facial nerve injury were 9.2% and 5.2% respectively, the risk of which increased with old age, malignant tumour and revision surgery. Traditional the incidental of facial nerve injury is reduced by intra-operative facial nerve monitoring and surgical magnification, while imaging has limited role in aiding this purpose. However with advancement in MRI technique high resolution three-dimensional sequences (i.e. neurogram sequences) are available for better visualization of branches of facial nerves. The investigators would therefore aim to demonstrate additional efficacy of these techniques and also to compare with conventional 3D post-contrast anatomical imaging studies in the localization and visualization of the facial nerve branches in patients with tumour. With better pre-operative imaging, the investigators hope to reduce the chance of facial nerve injury in these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Imaging group | Experimental | patients with parotid tumour being imaged |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging on 3T scanner (Magnetom Prisma, SIemens) with dedicated neurogram sequences (Constructive interference in steady state - CISS; Dual Echo Steady State - DESS) | Diagnostic Test | The MRI examination will consist of both conventional sequences for diagnosis of salivary gland neoplasms (including DWI and DCE-MRI), together with additional neurogram sequences. (please refer to attached protocol for list of sequences) |
| Measure | Description | Time Frame |
|---|---|---|
| visualization of the major branches of the facial nerve on MRI sequences | The degree which facial nerve and branches will be visualized, by a three-point scale to each facial nerve branch, after review by radiologist. Total score of facial nerve visualization will be calculated, per MRI sequence per patient. | At MRI scan before therapeutic intervention (operation or radiofrequency ablation) |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic value of multi-parametric MRI | The sensitivity, specificity and accuracy of MRI on distinguishing benign and malignant parotid tumours using DWI and DCE-MRI. | At MRI scan before therapeutic intervention (operation or radiofrequency ablation) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gerald Choa MRI Center CUHK | Contact | 852-35051009 | cumri@cuhk.edu.hk | |
| Ho Sang Leung, MBBS (HK) | Contact | 852-55699208 | lhs655@ha.org.hk |
| Name | Affiliation | Role |
|---|---|---|
| Ho Sang Leung, MBBS (HK) | Department of Imaging and Interventional Radiology, Prince of Wales Hospital | Principal Investigator |
| Chiu Wing WInnie Chu, MD, FHKCR | Department of Imaging and Interventional Radiology, Prince of Wales Hospital |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gerald Choa MRI Center | Recruiting | Hong Kong | Hong Kong |
Data to be shared includes individual participant data that underlie the results reported in this article, after deidentification.
Within 3 years after publication of article.
Proposals should be directed to lhs655@ha.org.hk. To gain access, data requestors will need to sign a data access agreement. Data are available for 3 years at CUHK research data repository. (https://researchdata.cuhk.edu.hk//)
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 6, 2022 | Sep 7, 2023 |
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|
| Prot_002.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 9, 2022 | Sep 7, 2023 | ICF_003.pdf |
| ID | Term |
|---|---|
| D010307 | Parotid Neoplasms |
| ID | Term |
|---|---|
| D012468 | Salivary Gland Neoplasms |
| D009062 | Mouth Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010305 | Parotid Diseases |
| D012466 | Salivary Gland Diseases |
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