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Juvenile idiopathic arthritis (AJI), is a frequent inflammatory disease in children, characterized by pain, arthritis, and deformities. Chronic inflammation leads to physical inactivity and can be associated with muscle weakness around affected joints, low bone strength, and mass(3). To our knowledge, no study has focused on the prevalence of sarcopenia in JIA and the data on the muscle disorder are lacking. The purpose of the present study is to detect sarcopenia and identify associated factors in children with JIA
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | healthy children aged between 4-16 years |
| |
| 2 | children aged between 4-16 years, suffering from juvenile idiopathic arthritis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| densitometry/ handgrip dynamometer | Diagnostic Test | all patients will undergo the Dual-energy X-ray absorptiometry (DXA) and the muscle strength assessment using the handgrip dynamometer |
| Measure | Description | Time Frame |
|---|---|---|
| skeletal muscle mass | Dual-energy X-ray absorptiometry (DXA) measures the appendicular lean mass ( the sum of the lean mass of the arms and legs) and adjusted to the body mass index | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| muscle strenght | Three consecutive trials will be measured by the handgrip dynamometer between the dominant and non-dominant sides. the highest value will be used and adjusted to the body mass index | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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For all patients, we collected the anthropometric data including weight, height, and expressed it as Z scores for age and sex. Body mass index (BMI) was calculated as weight (kg)/height (m2). The disease duration, AJI subtype, disease activity, and treatment were recorded.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37682255 | Derived | Lassoued Ferjani H, Majdoub F, Ben Nessib D, Kaffel D, Triki W, Maatallah K, Hamdi W. Sarcopenia: a new issue in juvenile idiopathic arthritis. A study Protocol. Tunis Med. 2023 Jan 2;101(1):15-18. |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D001171 | Arthritis, Juvenile |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |