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| Name | Class |
|---|---|
| University of Saskatchewan | OTHER |
| Saskatchewan Food Industry Development Center | UNKNOWN |
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The study looks at the comparative effects of food products made with pea, lentil, and oat flour of various particle sizes on postprandial glycemic response, appetite and food intake, and amino acid release in healthy adults.
A total of 60 participants (30 males, 30 females) will take part in this study at the University of Toronto. Twenty participants will be recruited to each one of three trials (pea, lentil or oat) and will attend 4 study sessions where they will consume crackers/porridge made with pea, lentil, oat, or wheat flours of different particle sizes. Questionnaires will be filled out to assess their recent food intake, physical activity, sleep quality, stress level, appetite, physical comfort, and energy/fatigue level, as well as tastefulness of the food. Blood samples will be collected at fasting and at various time points over a 2 hour period after eating to measure blood glucose, insulin, and amino acid concentrations. Before leaving, participants will receive an all-you-can-eat pizza meal to assess their food intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pea | Experimental | Treatment 1: crackers made with 25% whole pea flour + 75% all-purpose wheat flour; Treatment 2: crackers made with 25% coarse pea flour + 75% all-purpose wheat flour; Treatment 3: crackers made with 25% fine pea flour + 75% all-purpose wheat flour; Treatment 4: crackers made with 100% all-purpose wheat flour (control) |
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| Lentil | Experimental | Treatment 1: crackers made with 25% whole lentil flour + 75% all-purpose wheat flour; Treatment 2: crackers made with 25% coarse lentil flour + 75% all-purpose wheat flour; Treatment 3: crackers made with 25% fine lentil flour + 75% all-purpose wheat flour; Treatment 4: crackers made with 100% all-purpose wheat flour (control) |
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| Oats | Experimental | Treatment 1: porridge made with whole oat flour; Treatment 2: porridge made with coarse oat flour; Treatment 3: porridge made with fine oat flour; Treatment 4: porridge made with commercial oat flour (control) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Crackers made with whole, coarse, or fine pea and/or wheat flour | Other | Participants will consume 1 of the 4 treatments at each of 4 study sessions in random orders such that by the end of the study, they will have consumed all 4 treatments. They will be given 10 minutes to consume the entire treatment with a glass of water. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in postprandial glycemic response | Blood collection via finger prick to analyze blood glucose (glucometer reading) and serum insulin concentration (μIU/mL). | Blood glucose will be measured at baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption. Insulin will be measured at baseline and every half an hour after treatment consumption over 2 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite | Motivation to Eat Adaptive Visual Analogue Scales measured based on a score between 0 to 100. A higher score indicates higher outcome. | At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption. |
| Food intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| G. Harvey Anderson, PhD | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutritional Sciences | Toronto | Ontario | M5S 3E2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39366276 | Derived | Zhou CZC, Anderson GH, Fan W, Vien S, Ai Y, Tulbek M, Fabek H. Increasing particle size of oat flours decreases postprandial glycemia and increases appetite in healthy adults. Nutr Res. 2024 Oct;130:81-94. doi: 10.1016/j.nutres.2024.07.006. Epub 2024 Jul 25. |
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Randomized, controlled, crossover acute trial
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| Crackers made with whole, coarse, or fine lentil and/or wheat flour | Other | Participants will consume 1 of the 4 treatments at each of 4 study sessions in random orders such that by the end of the study, they will have consumed all 4 treatments. They will be given 10 minutes to consume the entire treatment with a glass of water. |
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| Porridge made with oat flour | Other | Participants will consume 1 of the 4 treatments at each of 4 study sessions in random orders such that by the end of the study, they will have consumed all 4 treatments. They will be given 10 minutes to consume the entire treatment with a glass of water. |
|
Measured via amount of pizza (g) consumed at an ad libitum pizza meal. |
| 2 hours after treatment consumption. |
| Protein quality | Intravenous blood collection to analyze amino acid concentrations (μmol/L) to determine amino acid release. | At baseline and every half hour after treatment consumption over a period of 2 hours, and after pizza meal. |
| Physical comfort | Physical Comfort Visual Analogue Scales measured based on a score between 0 to 100. A higher score indicates higher outcome. | At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption. |
| Energy & fatigue | Energy and Fatigue Visual Analogue Scales measured based on a score between 0 to 100. A higher score indicates higher outcome. | At baseline and at 15, 30, 45, 60, 90, 120, and 140 minutes after treatment consumption. |
| Treatment palatability | Treatment Palatability Visual Analogue Scales measured based on a score between 0 to 100. A higher score indicates higher outcome. | Immediately after treatment consumption. |
| ID | Term |
|---|---|
| D044342 | Malnutrition |
| D003920 | Diabetes Mellitus |
| D007732 | Kwashiorkor |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D000067011 | Severe Acute Malnutrition |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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