Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy

Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy: a Multicenter, Randomized, Controlled Clinical Study

The clinical purpose of this study was to investigate whether the adjuvant application of linaclotide in bowel preparation for colonoscopy could improve the quality of bowel preparation or reduce the dosage of laxatives.

Inclusion Criteria:

• 18-75 years old, male or female;
• To undergo diagnostic, screening or monitoring colonoscopy;
• Signed written informed consent;

Exclusion Criteria:

• Severe cardiopulmonary insufficiency, renal failure or a history of stroke or myocardial infarction within six months;
• History of abdominal or pelvic surgery;
• Pregnant and lactating women;
• BMI > 28, BMI < 18.5, inflammatory bowel disease, constipation (defecation less than 3 times in the last week, and laborious defecation, fecal sclerosis, low volume) or intestinal obstruction and other high-risk factors of intestinal preparation;
• Abnormal coagulation function or taking antiplatelet or anticoagulant drugs within 7 days;
• Warning symptoms and signs of colorectal cancer: hematochezia, melena, unexplained anemia, low body weight, abdominal mass, positive digital rectal test; or imaging and laboratory tests highly suspect colorectal cancer;
• Colon polyps have been identified;
• Stow score 7 (watery, no solid mass), diarrhea was considered;
• Participation in other interventional clinical trials within 60 days.