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Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.
Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MIdazolam Group | Experimental | Following surgery Immediately after shifting in ICU, midazolam infusion were administered as 0.25 mg/kg/min. |
|
| Propofol Group | No Intervention | Following surgery after Immediately shifting in ICU propofol infusion was started at 10µg/kg/min. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Midazolam | Drug | Midazolam infusion will be given after the surgery as 0.25 mg/kg/min. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of post-surgery sedation | Duration of post-surgery sedation following cardiac surgery | Time in minutes calculated from end of surgery to the time of awakening up to 24 hours in both study groups |
| Time taken to post-surgery extubation | Time taken from the end of cardiac surgery to post-surgery extubation | Time taken in minutes from the end of the cardiac surgery to post-surgery extubation up to 1 week duration in both study groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shumaila Rai, MBBS | Ch. Pervaiz Elahi Institute of Cardiology, Multan, Pakisan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ch. Pervaiz Elahi Institute of Cardiology | Multan | Punjab Province | 59341 | Pakistan |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D008874 | Midazolam |
| ID | Term |
|---|---|
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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Radomized Controlled Trial
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Open label
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006571 | Heterocyclic Compounds |