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Some studies have reported that intravenous esketamine reduce postoperative pain intensity. The investigators investigated whether esketamine could improve the the quality of recovery after modified radical mastectomy.
A total of 111 patients were randomly allocated into 3 groups. Patients in group LE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. Patients in group HE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. Patients in group CON received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-dose esketamine infusion on the quality of recovery after radical mastectomy | Experimental | Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. |
|
| High-dose esketamine infusion on the quality of recovery after radical mastectomy | Experimental | Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. |
|
| Saline infusion on the quality of recovery after radical mastectomy | Experimental | Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-dose esketamine infusion | Drug | Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of recovery scores (QoR-15) | Our primary outcome was quality of recovery scores (QoR-15) 1 day after operation | 1 day after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Pain visual analogue scale scores | Secondary Outcome Measure was pain visual analogue scale scores | The first 48 hours after operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anqing Hospital Anesthesiology | Anqing | Anhui | 246000 | China |
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| High-dose esketamine infusion | Drug | Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. |
|
| Saline infusion | Drug | Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin. |
|