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| Name | Class |
|---|---|
| epHealth | UNKNOWN |
| Novartis | INDUSTRY |
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A cross-sectional real-world data study designed to assess the use of statins in individuals assisted within the primary care system in Brazil.
Considering the high cardiovascular risk associated to high cholesterol levels, assessing the use of statins in secondary prevention as well as primary prevention individuals in real world settings is key to enable public health policy improvements.
The aim of the present study is to assess statins use in primary and secondary prevention individuals assisted by community care workers in the primary care system in Brazil, using a free real world data collection tool (epHealth database). Evaluating factors associated with statins use as well as high dose statins use are also objectives of the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Secondary prevention | Individuals with previous myocardial infarction and/or stroke |
| |
| Primary prevention | Individuals with hypertension, diabetes and/or dyslipidemia |
| |
| Unknown diagnosis | Individuals without a previous myocardial infarction and/or stroke or a diagnosis of hypertension, diabetes and/or dyslipidemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Statin | Drug | Statin use |
|
| Measure | Description | Time Frame |
|---|---|---|
| Statin use on secondary prevention | Proportion of patients with previous myocardial infarction and/or stroke on statin use | Baseline |
| Statin use on primary prevention | Proportion of patients with hypertension, diabetes and/or dyslipidemia on statin use | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Statin use on patients with previous myocardial infarction | Proportion of patients with previous myocardial infarction on statin use | Baseline |
| Statin use on patients with previous stroke | Proportion of patients with previous stroke on statin use |
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Inclusion Criteria:
Exclusion Criteria:
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All individuals aged 18 years or older registered on the epHealth database will be used in this study.
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| Name | Affiliation | Role |
|---|---|---|
| M. Julia Machline-Carrion, PhD | epHealth | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Israelita Albert Einstein | São Paulo | São Paulo | 04561-000 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37497398 | Result | Machline-Carrion MJ, Girotto AN, Nieri J, Pereira PM, Monfardini F, Forestiero F, Raupp P, Roveda F, Santo K, Berwanger O, Santos RD. Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach. Lancet Reg Health Am. 2023 Jun 22;23:100534. doi: 10.1016/j.lana.2023.100534. eCollection 2023 Jul. | |
| 38431498 |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009203 | Myocardial Infarction |
| D020521 | Stroke |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| D050171 | Dyslipidemias |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
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| ID | Term |
|---|---|
| D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| D019821 | Simvastatin |
| D000068718 | Rosuvastatin Calcium |
| D000069059 | Atorvastatin |
| C108475 | pitavastatin |
| D017035 | Pravastatin |
| D008148 | Lovastatin |
| ID | Term |
|---|---|
| D000924 | Anticholesteremic Agents |
| D000960 | Hypolipidemic Agents |
| D000963 | Antimetabolites |
| D045504 | Molecular Mechanisms of Pharmacological Action |
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| Baseline |
| High dose statin use on secondary prevention | Proportion of patients with previous myocardial infarction and/or stroke on high dose statin use | Baseline |
| High dose statin use on patients with previous myocardial infarction | Proportion of patients with previous myocardial infarction on high dose statin | Baseline |
| High dose statin use on patients with stroke | Proportion of patients with previous stroke on high dose statin | Baseline |
| Statin use on patients with diabetes | Proportion of patients with diabetes on statin use | Baseline |
| Statin use on patients with hypertension | Proportion of patients with hypertension on statin use | Baseline |
| Statin use on patients with dyslipidemia | Proportion of patients with dyslipidemia on statin use | Baseline |
| High dose statin use on patients with diabetes | Proportion of patients with diabetes on high dose statin | Baseline |
| High dose statin use on patients with hypertension | Proportion of patients with hypertension on high dose statin | Baseline |
| High dose statin use on patients with dyslipidemia | Proportion of patients with dyslipidemia on high dose statin | Baseline |
| Statin use on patients with unknown diagnosis | Proportion of patients without previous myocardial infarction and/or stroke or a diagnosis of hypertension, diabetes and/or dyslipidemia on statin use | Baseline |
| High dose statin use on patients with unknown diagnosis | Proportion of patients without previous myocardial infarction and/or stroke or a diagnosis of hypertension, diabetes and/or dyslipidemia on high dose statin use | Baseline |
| Result |
| Santo K, Santos RD, Girotto AN, Nieri J, Monfardini F, Raupp P, Pereira PM, Berwanger O, Machline-Carrion MJ. Statins use for primary prevention of cardiovascular disease: A population-based digitally enabled real-world evidence cross-sectional study in primary care in Brazil. J Clin Lipidol. 2024 May-Jun;18(3):e384-e393. doi: 10.1016/j.jacl.2024.02.005. Epub 2024 Feb 20. |
| D007511 |
| Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D052439 | Lipid Metabolism Disorders |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D004791 | Enzyme Inhibitors |
| D057847 | Lipid Regulating Agents |
| D045506 | Therapeutic Uses |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011083 | Polycyclic Compounds |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D005464 | Fluorobenzenes |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006538 | Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |