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| Name | Class |
|---|---|
| Aalborg University | OTHER |
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The investigators hypothesize gold is inert and thereby there is no pure-gold allergy. The primary aim of this study is to measure the prevalence of allergy to metallic pure gold microparticles and allergy to GSTS.
TRUE test panel which includes gold sodium thiosulphate (GSTS), 1 % w/v in petrolatum, and gold microparticles, 20-micron diameter, 1 % w/v in petrolatum, will be added added to the baseline series. It will be applied to the upper back of healthy adults in aluminum Finn Chamber for 48 hours. Clinical evaluation will be performed 24 hours after removal the test according to standard procedures for evaluation of epi-cutaneous challenging (Johansen 2015).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gold microparticles | Experimental | Metallic gold microparticles, 20-micron diameter, 1 % w/v in petrolatum |
|
| Gold thiosulphate | Active Comparator | Gold Sodium Thio Sulphate, 1 % w/v in petrolatum |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gold microparticles | Other | Metallic gold microparticles, 20-micron diameter, 1 % w/v in petrolatum |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patch test | Test materials will be applied on the upper back of the volunteers in aluminium Finn Chambers for 48 hours. Clinical evaluation will be performed 24 hours after removal of the test substances according to standard procedures for evaluation of epicutaneous challenging according to criteria of ICDRG (International Contact Dermatitis Research Group) (Johansen 2015). Reactions: doubtfull, faint macular erythema only; weak positive reaction, erythema, infiltration papules; strong positive reaction, erythema, infiltration, papular, vesicles; erythema positive reaction, intense erythema, infiltration and coalescing vesicles; negative reaction; irritant reaction; not tested | 72 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sten Rasmussen, PhD | Contact | 25520462 | sten@dcm.aau.dk |
| Name | Affiliation | Role |
|---|---|---|
| Sten Rasmussen, PhD | Department of Clinical Medicine, Aalborg Unviversity | Principal Investigator |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D010328 | Patch Tests |
| ID | Term |
|---|---|
| D012882 | Skin Tests |
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| Gold thiosulphate | Other | Gold Sodium Thio Sulphate, 1 % w/v in petrolatum |
|
|
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |