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| Name | Class |
|---|---|
| Liverpool University Hospitals NHS Foundation Trust | OTHER_GOV |
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This study will verify the effects of breaking up sitting time with short bouts of light intensity walking on vascular function in women with rheumatoid arthritis.
Women diagnosed with rheumatoid arthritis will participate in this randomized crossover trial. In one of the experimental sessions, the participants will remain 4-h on uninterrupted sitting, and in another day they will perform 3-min light intensity walk every 30 min to break up the sitting position. Vascular function will be assessed before and after each intervention using the following devices/techniques: a) transcranial Doppler ultrasound to assess the middle cerebral artery blood flow velocity at baseline and in response to CO2 breathing (5% CO2 mixture for 3 min), and to repeated sit-to-stand transitions; b) a multi-frequency linear transducer (7-12 MHz) attached to a high-resolution ultrasound machine to assess femoral artery dilation after reactive hyperemia (i.e., flow-mediated dilation); c) a laser Doppler probe attached to the skin surface of the right shin in order to quantify the Laser Doppler flux at baseline and during reactive hyperemia. Additionally, healthy age- and body mass-matched women will be recruited and will only perform the pre-intervention tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Walking breaks (WALK) | Experimental | During this session, participants will be requested to remain seated during 4 hours, but the sitting will be interrupted every 30 min with a 3-min light-intensity walking. |
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| Prolonged sitting (SIT) | No Intervention | During this session, participants be requested to remain seated during 4 uninterrupted hours (excepted for visiting the toilet) in a comfortable chair |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical activity | Behavioral | Multiple bouts of 3-min brisk walking, every 30 min, for 4 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Middle cerebral artery mean velocity (MCAV) | MCAV will be assessed using continuous bilateral transcranial Doppler ultrasound. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Middle cerebral artery mean velocity reactivity to carbon dioxide | Participants will breathe a 5% carbon dioxide mixture for 3 min during which time MCAV reactivity to CO2 will be assessed using continuous bilateral transcranial Doppler ultrasound. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Cerebral autoregulation | Participants will be asked to complete a series of repeated sit to stand moves (coached by a member of the research team) for a 5-minute period, during which time MCAV will be assessed using continuous bilateral transcranial Doppler ultrasound. Beat by beat blood pressure will also be assessed using finger photoplethysmography. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial artery endothelial function | Brachial artery endothelial function will be assessed through flow-mediated dilation using vascular ultrasound. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Finger blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daniel Bannell, MPhil | Contact | 07786008666 | 44 | D.J.Bannell@2015.ljmu.ac.uk |
| David Low, PhD | Contact | 01519046244 | 44 | d.a.low@ljmu.ac.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Institute for Sport and Exercise Sciences (RISES) | Recruiting | Liverpool | Merseyside | L3 3AF | United Kingdom |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| D012216 | Rheumatic Diseases |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D003240 | Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D016138 | Walking |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Participants with rheumatoid arthritis will attend the laboratory at Liverpool John Moores University on 2 occasions. During these visits, they will be submitted to the intervention or the control and will also undertake a series vascular tests prior- and post-intervention/control.
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The researcher who will perform the vascular analysis will be blinded to the allocation order.
During all procedures, beat by beat finger blood pressure will be measured on the middle finger of the right hand using photoplethysmography.
| Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Superficial femoral artery endothelial function | Superficial femoral artery endothelial function will be assessed through flow-mediated dilation using vascular ultrasound. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Skin blood flow response to hyperemia | Skin blood flow response to hyperemia will be assessed using a laser doppler probe attached to the shin and forearm. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Stroop color-word test | The Stroop color-word test will be implemented to assess attention and inhibitory control. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| California Verbal Learning Test-2 | Immediate recall of the California Verbal Learning Test-2 will be used to assess verbal learning and memory. | Change from baseline (hour 0) to hour 4 (post-intervention/control) |
| Brachial artery blood flow | Vascular ultrasound will be used to assess brachial artery blood flow every hour during the intervention | Change from baseline to 1-hour/2-hour/3-hour/4-hour |
| Femoral artery blood flow | Vascular ultrasound will be used to assess femoral artery blood flow every hour during the intervention | Change from baseline to 1-hour/2-hour/3-hour/4-hour |
| Pain intensity | Pain intensity will be assessed using a 10cm visual analogue scale. | Change from baseline to 1-hour/2-hour/3-hour/4-hour |
| D017437 |
| Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D001519 | Behavior |
| D008124 | Locomotion |