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The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome at UZ Brussel hospital (UZB).
The monocentric UZB registry for Brugada registry is intended to collect all data on patients affected by Brugada syndrome.
These includes:
3) data on the families: number of family members, sudden death history. 4) data on the genetics 5) data on: ECG, echocardiography, CT scan, MRI of heart, MRI of brain, ECG imaging, 3D electroanatomical mapping and ablation
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention because it is a patient registry | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Ventricular arrhythmias | Composite of: sudden cardiac death, aborted sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, ICD appropriate therapy | through study completion, an average of 10 year |
| Atrial fibrillation | Atrial fibrillation occurrence | through study completion, an average of 10 year |
| Death for any cause | Death for any cause | through study completion, an average of 10 year |
| Cardiovascular death | Death for cardiovascular cause | through study completion, an average of 10 year |
| Genetic mutations | Genetic mutations (pathogenic and variant of unknown significance) associated with Brugada syndrome. Wide gene panel with next generation sequencing will be used: Roche SeqCap® EZ Human Exome Probes v3.0 for BrS. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Brugada syndrome patients diagnosed following current guidelines: (Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015;36:2793-2867.) Both Brugada spontaneous type 1 and ajmaline induced will be included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carlo de Asmundis, MD, PhD | Contact | +32024763704 | hrmc@uzbrussel.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Brussel Heart Rhythm Management Center | Recruiting | Brussels | 1090 | Belgium |
No IPD sharing
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| ID | Term |
|---|---|
| D053840 | Brugada Syndrome |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
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Blood sample for DNA analysis
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |