This is a observational study to identify the key factor associated with vasospastic angina and to explore the prognosis of the participants. The study will recruit 400 patients with vasospastic angina, 400 healthy controls and 400 patients with acute myocardial infarction. Next generation sequencing, metabolome and proteomics will be performed in these participants.

Inclusion Criteria:

• 18 years of age or older
• diagnosed as vasospastic angina

Exclusion Criteria:

• participate in any drug clinical trials within 3 months
• patients with life-threatening complications, or the researchers determined that the survival time of patients with no more than 1 years
• serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients)
• previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix)

Chinese patients with vasospastic angina