second efficacy parameter in prostaglandin associated peri-orbitopathy diseases at 24 weeks compared to baseline.

-Upper eyelid ptosis Margin reflex distance (MRD) is measured, and MRD 1 and MRD 2 are measured, respectively.

This is measured to evaluate the palpebral fissure height.

Grading is evaluated by the difference between the values of MRD 1 and MRD 2. mild = less than 2 mm; moderate = more than 2 mm and less than 4 mm; severe = more than 4 mm;

second efficacy parameter in prostaglandin associated peri-orbitopathy diseases at 24 weeks compared to baseline.

-Periorbital hyperpigmentation Periorbital hyperpigmentation around the eyes is evaluated compared to the surrounding skin.

Grading is evaluated from 0 to 4 points. grade 0 = skin color comparable to other facial skin areas; grade 1 = faint pigmentation of infraorbital fold; grade 2 = pigmentation more pronounced; grade 3 = deep dark color, all four lids involved; grade 4 = grade 3+ pigmentation spreading beyond infraorbital fold;

second efficacy parameter in prostaglandin associated peri-orbitopathy diseases at 24 weeks compared to baseline.

Facial photos, including eyebrows and lower eyelids, are taken by the investigator with the same digital camera and without flash in the same room conditions.

When registering participants, the principal investigator of the conducting institution evaluates and registers participants, and the final evaluation is evaluated by three independent evaluators by randomly arranging the pictures taken during the visit so that the order of the visit is unknown.

second efficacy parameter in intraocular pressure at 24 weeks compared to baseline.

second efficacy parameter in Response rate of changes in intraocular pressure at 24 weeks compared to baseline.

- Conjunctival Hyperemia Conjunctival Hyperemia is performed according to the evaluation criteria of the Japanese Ocular Allergy Society (JOAS).

Grading is evaluated from 0 to 3 points. Grade 0 = No vasodilation; Grade 1= Some vessel vasodilation; Grade 2 = Excessive vessel vasodilation; Grade 3 = Overall vasodilation;

-Macular Edema

Inspect with Optical Coherence Tomography.

Clinically significant macular edema in the following cases evaluate.

• Thickening of the retina at or within 500 μm of the center of the macula.
• Hard exudates at or within 500 μm of the center of the macula that associated with thickening of adjacent retina (which may lie more than 500 μm from the center of the macula).
• A zone or zones of retinal thickening 1 disc area or larger, any part of which is within 1 disc diameter of the center of the macula

-Cystoid Macular Edema

Inspect with Optical Coherence Tomography. CME I = cysts less than 30% macular thickness; CME II = cysts between 30% and 60% of macular thickness; CME III = cysts between 60% and 90% of macular thickness; CME IV = cysts became more than 90% of the macular thickness;

-Endothelial Cell Count

Measure with a specular microscope and check CD (Cell Density, cells/mm^2), CV (Coefficient of Variation), HEX (Hexagonality, %), NUM (number excluding incorrect count cells when counting cells) do.

-Central Cornea Thickness

After eye drop anesthesia, it is measured with an Ultrasonic Pachymeter(μm).