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The current observational registry aims to evaluate in patients undergoing TAVI implantation:
The persistent growth in transcatheter aortic valve implantation (TAVI) calls for optimized early discharge programs to handle the increasing patient load. While access site bleeding and stroke rate have decreased with improved technologies and operators' experience, acquired conduction abnormalities necessitating prolonged rhythm-monitoring and permanent pacemaker (PPM) implantation have remained largely unchanged, and even up to 39.9% for some TAVI platforms. Prompt identification of patients necessitating PPM implantation leads to optimal patient care and use of resources. Conversely, prompt identification of patients with low -to no- risk for PPM post TAVI shortens their hospitalization and facilitates early and safe discharge.
Several baseline characteristics such as age, preexistent right bundle branch block (RBBB) and the use of self-expanding valves are associated with post-TAVI PPM implantation, but more practical and clinically more relevant parameters are needed with high negative and positive predictive values that could support clinical decision-making.
En passant rapid atrial pacing (RAP) immediately following TAVI has recently been reported to be a valuable tool in PPM risk stratification. The absence of Wenckebach phenomena post implantation at RAP up to 120/' has a negative predictive value for PPM of 98.7%.2 First use of RAP in routine practice at AZ Sint Jan Brugge can confirm these first results (unpublished data). This technique improves our clinical assessment and identification of low-risk patients for PPM suitable for safe early discharge, as well as high-risk patients requiring further rhythm monitoring and eventual PPM implantation.
The current observational registry aims to evaluate in patients undergoing TAVI implantation:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RAP TAVI group | All patients in sinus rhythm with TAVI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RAP TAVI | Procedure | All patients undergoing TAVI with no pre-existing pacemaker and in sinus rhythm at the time of the procedure will receive RAP by placing the temporary wire in the right atrium |
| Measure | Description | Time Frame |
|---|---|---|
| Positive and negative predictive value of RAP for PPM implantation post TAVI | 1 month after TAVI | |
| Permanent pacemaker implantation | 1 month after TAVI | |
| New conduction abnormalities | within 1 week after TAVI |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of hospitalization | 1 month after TAVI | |
| Echocardiographic changes | 1 month after TAVI | |
| Stroke |
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Inclusion Criteria:
Exclusion Criteria:
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500 patients in sinus rhythm undergoing TAVI
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ian Buysschaert, MD, PhD | Contact | +32050452670 | ian.buysschaert@azsintjan.be | |
| Emma Christiaen, Msc | Contact | +32050453293 | Emma.Christiaen@azsintjan.be |
| Name | Affiliation | Role |
|---|---|---|
| Ian Buysschaert, MD, PhD | AZ Sint Jan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Algemeen Stedelijk Ziekenhuis Aalst | Recruiting | Aalst | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41884902 | Derived | De Cock E, Adriaenssens T, Stammen F, Vanderheyden M, Dubois C, Vanhaverbeke M, Ferdinande B, Pirlet C, Simon F, Vandeloo B, Lesizza P, Rosseel L, Aminian A, Scott B, De Vroey F, Christiaen E, le Polain de Waroux JB, Van der Heyden J, Buysschaert I. Rapid Atrial Pacing-Induced Wenckebach Atrioventricular Block: A Poor Predictor of Permanent Pacemaker Need Post-TAVR. Circ Cardiovasc Interv. 2026 May;19(5):e016145. doi: 10.1161/CIRCINTERVENTIONS.125.016145. Epub 2026 Mar 26. |
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 1 month after TAVI |
| Major vascular bleeding | 1 month after TAVI |
| New pericardial effusion | 1 month after TAVI |
| All-cause mortality | 1 month after TAVI |
| OLV Aalst | Recruiting | Aalst | Belgium |
|
| ZNA Middelheim | Recruiting | Antwerp | Belgium |
|
| AZ Sint Jan | Recruiting | Bruges | 8000 | Belgium |
|
| CHU Charleroi-Chimay | Recruiting | Charleroi | Belgium |
|
| Grand Hôpital de Charleroi | Recruiting | Charleroi | Belgium |
|
| Ziekenhuis Oost-Limburg | Recruiting | Genk | Belgium |
|
| UZ Brussel | Recruiting | Jette | Belgium |
|
| UZ Leuven | Recruiting | Leuven | Belgium |
|
| Citadelle Hospital | Recruiting | Liège | Belgium |
|
| Clinique Saint-Luc Bouge | Recruiting | Namur | Belgium |
|
| AZ Delta | Recruiting | Roeselare | Belgium |
|
| D014694 |
| Ventricular Outflow Obstruction |