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The study is an observational prospective evaluation of an approved and unchanged clinical management, evaluating different diagnosis methods to assess brain perfusion in patients with an aneurysmal or AVM-related intracranial hemorrhage
The study is a prospective description and evaluation of an approved and unchanged clinical management, evaluating already used different diagnosis methods to assess brain perfusion in patients with atraumatic (aneurysmal, AVM-related, unknown cause) intracranial hemorrhage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Evolution of brain imaging in Non-traumatic Intracranial Hemorrhage | This study will use an established local protocol for DCI and intracranial arterial vasospastic stenosis screening, and follow-up to make sure that all patients have the same protocol and don't lose any chance of improvement and good outcome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain computed tomography | Diagnostic Test | This study will use an established local protocol for DCI and intracranial arterial vasospastic stenosis screening, and follow-up to make sure that all patients have the same protocol and don't lose any chance of improvement and good outcome : CT perfusion at different time intervals |
| Measure | Description | Time Frame |
|---|---|---|
| Change in brain hypoperfusion | Brain hypoperfusion in arterial territories assessed by the delays on perfusion Time to drain (seconds) on CT and/or MR perfusion | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Measure | Description | Time Frame |
|---|---|---|
| Change in vessel size | Change in the vessel size measured on digital subtraction angiography (DSA) and computed tomography angiogram (CTA) in millimeters | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Time to next endovascular intervention for vasospastic stenosis |
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i. Inclusion Criteria
ii. Exclusion Criteria
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Patients who fit the inclusion criteria (suffered a non-traumatic (aneurysmal, AVM-related, unknown cause) intracranial hemorrhage) will be included prospectively.
The deadline for data collection November, 2031 Data analysis will be performed when judged necessary by the investigators.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Comite ethique hopital Erasme | Contact | 003225553707 | comite.ethique@erasme.ulb.ac.be | |
| Boris Lubicz, MD, PhD | Contact | 003225553998 | Boris.Lubicz@erasme.ulb.ac.be |
| Name | Affiliation | Role |
|---|---|---|
| Adrien Guenego, MD | Erasme University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme Hospital | Recruiting | Brussels | 1070 | Belgium |
No data sharing
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| ID | Term |
|---|---|
| D017542 | Aneurysm, Ruptured |
| D013345 | Subarachnoid Hemorrhage |
| D001165 | Arteriovenous Malformations |
| D002532 | Intracranial Aneurysm |
| D020300 | Intracranial Hemorrhages |
| ID | Term |
|---|---|
| D000783 | Aneurysm |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002561 | Cerebrovascular Disorders |
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|
Delay between two procedures for the same indication |
| Number of days after the endovascular procedure until the next procedure in days, up to 4 weeks |
| Transcranial Doppler | Reduction in intracranial vasospasm assessed by the targeted vessel velocity in meters per second | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Brain Hypoperfusion 2 | Reduction in brain hypoperfusion assessed by the volumes on different perfusion parameters time to peak (in seconds) on CT and/or MR perfusion | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Change in Glasgow coma scale | Glasgow coma scale (GCS between 3 and 15, a higher score means a better outcome) | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Change in National Institutes of Health Stroke Scale score | National Institutes of Health Stroke Scale (NIHSS between 0 and 42, a higher score means a worse outcome) | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Change in the monitoring of tissue oxygen pressure (PtiO2) | Monitoring of tissue oxygen pressure (PtiO2) | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Change in the number of new ischemic lesions | Number of new ischemic lesions on non-contrast CT scan | Change between day 0, 5, 9, 21 after Intracranial Hemorrhage |
| modified Rankin Scale at 3 months | clinical evolution (mRS between 0 and 6, a higher score means a worse outcome) | 3 months after Intracranial Hemorrhage |
| Change in brain hypoperfusion 3 | Brain hypoperfusion in arterial territories assessed by the delays on perfusion parameters TMax maps in seconds on CT and/or MR perfusion | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| Change in brain hypoperfusion 4 | Brain hypoperfusion in arterial territories assessed by the delays on perfusion parameters Mean transit time on CT and/or MR perfusion in seconds | Change between day 0, 5, 9 after Intracranial Hemorrhage |
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D054079 | Vascular Malformations |
| D018376 | Cardiovascular Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D020765 | Intracranial Arterial Diseases |