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| Name | Class |
|---|---|
| Beni-Suef University | OTHER |
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Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.
Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count.
Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
On the first postoperative day corneal edema in control compared to dexamethasone and TA groups respectively.
One month later, the mean increase of corneal thickness in control compared to intracameral dexamethasone and TA groups, respectively.
mean endothelial cell loss in control compared to intracameral dexamethasone and TA groups respectively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group 1 | Sham Comparator | 23 eyes that did not receive any intraoperative steroids |
|
| Dexamethasone group 2 | Active Comparator | 23 eyes that received intracameral dexamethasone |
|
| Triamcinolone (TA) group 3 | Active Comparator | 23 eyes that received intracameral triamcinolone (TA) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control group | Other | 23 eyes that didn't receive any intraoperative steroids |
|
| Measure | Description | Time Frame |
|---|---|---|
| Corneal edema | Clinical grade of corneal edema on the first postoperative day | First day postoperative |
| Central corneal thickness (CCT) | Central corneal thickness in microns after phacoemulsification that was compared to preoperative values | Three months |
| Endothelial cell loss | Corneal endothelial cell count (cell/ square mm) after phacoemulsification that was compared to preoperative values | Three months |
| Measure | Description | Time Frame |
|---|---|---|
| IOP | Intraocular pressure in mmHg rise after after phacoemulsification | Three months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Khaled G Abueleinen, MD, PhD | Ophthalmology department, Faculty of Medicine Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Khaled G Abueleinen | Giza | Cairo Governorate | 12411 | Egypt |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 1, 2023 | |
| Reset | Feb 16, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 1, 2023 | Feb 16, 2024 |
| ID | Term |
|---|---|
| D015715 | Corneal Edema |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| D014221 | Triamcinolone |
| D044382 | Population Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count.
Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
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| Dexamethasone group | Drug | 23 eyes each received intracameral dexamethasone at the conclusion of phacoemulsification Received intracameral 0.4 mg in / 0.1 ml dexamethasone (8mg/2ml®; Amriya or Epico) at the end of phacoemulsification. |
|
|
| Triamcinolone (TA) group | Drug | 23 eyes each received intracameral triamcinolone (TA) at the conclusion of phacoemulsification Received intracameral 2 mg/0.05 ml triamcinolone (TA) (Kenacort-A®; Bristol-Myers Squibb) at the end of phacoemulsification. |
|
|
| D008722 | Methods |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D003710 | Demography |
| D011154 | Population Characteristics |