Revascularisation of Autotransplanted Teeth | NCT05267249

Studies
Revascularisation of Autotransplanted Teeth

NCT05267249

Sponsor

Medical University of Graz

Status

Completed

Last Update Posted

Mar 20, 2026Actual

Enrollment

16Actual

Phase

Not provided

Conditions

Endodontic Disease
Pulp Canal Obliteration

Interventions

Not provided

Countries

Austria

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

Large Document Module

Document Has No Statistical Analysis Plan (SAP)

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Mar 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Aug 6, 2021Actual

Primary Completion Date

Feb 1, 2022Actual

Completion Date

Feb 15, 2022Actual

First Submitted Date

Feb 23, 2022

First Submission Date that Met QC Criteria

Feb 23, 2022

First Posted Date

Mar 4, 2022Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Mar 17, 2026

Last Update Posted Date

Mar 20, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection

Note: The study was registered on Clinicaltrials.gov after termination of study.

Detailed Description

Not provided

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

16Actual

Label	Type	Description	Intervention Names
Autotransplantation		Autotransplantation and apicoectomy of mature teeth

Measure	Description	Time Frame
Survival	Tooth survival	1 year

Measure	Description	Time Frame
Revascularisation	Occurrence of Revascularisation	1 year

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Male and female consenting and judicious young people and adults
Written consent of the participant and, if applicable, of the legal guardian after education
Planned tooth transplantation with advanced or completed root growth

Exclusion Criteria:

Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw)
Current or past antiresorptive therapy with bisphosphonates
Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases
Acute gingivitis or advanced periodontitis
Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors)
heavy smokers (> 10 per day)
Acute or chronic infections (osteomyelitis) at the surgical site
metabolic diseases (diabetes, hyperparathyroidism, osteomalacia)
Severe kidney dysfunction, severe liver disease
Patients with high-dose corticosteroid therapy
prolonged corticosteroid or radiotherapy in the oral cavity
autoimmune diseases
Pregnant or breastfeeding women

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

12 Years

Maximum Age

70 Years

Standard Ages

ChildAdultOlder Adult

Study Population

Patients who underwent Autotransplantation of mature teeth with simultaneous apicoectomy between July 2017 and July 2020

Sampling Method

Non-Probability Sample

Name	Affiliation	Role
Petra Rugani, DDS	Medical University of Graz	Principal Investigator

Facility	Status	City	State	ZIP	Country	Contacts
Medical University of Graz		Graz	Styria	8010	Austria

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
29935869	Background	Jakse N, Ruckenstuhl M, Rugani P, Kirnbauer B, Sokolowski A, Ebeleseder K. Influence of Extraoral Apicoectomy on Revascularization of an Autotransplanted Tooth: A Case Report. J Endod. 2018 Aug;44(8):1298-1302. doi: 10.1016/j.joen.2018.04.016. Epub 2018 Jun 20.

ID	Term
D014076	Tooth Diseases
D009057	Stomatognathic Diseases