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An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months for all patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | 25 hemodialysis patients who received their routine therapy only. | |
| Selenium | Active Comparator | 23 hemodialysis patients who received Selenium 200µg once daily with their routine therapy just after the dialysis sessions for 3 months. |
|
| Alpha Lipoic acid | Active Comparator | 20 hemodialysispatients who received Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alpha lipoic acid | Drug | 20 patients who received Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in miRNA-126 level | Fold expression | 3 months |
| Change ROS level (ng/ml) | Using ELISA kit | 3 months |
| Change in Co Q10 level (ng/ml) | Using ELISA kit | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | 11566 | Egypt |
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| Selenium | Drug | 23 patients who received Selenium 200µg once daily with their routine therapy just a |
|
| ID | Term |
|---|---|
| D008063 | Thioctic Acid |
| D012643 | Selenium |
| ID | Term |
|---|---|
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D003067 | Coenzymes |
| D045762 | Enzymes and Coenzymes |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008903 | Minerals |
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