PI requested to close the study. No study activity since 2021 and no intent to publish results.

This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019.

This will be a single center, retrospective, before-and-after, chart review of all patients undergoing TTM between June 1, 2017 and May 31, 2021 at MDMC. Initiation of the new TTM protocol occurred on April 22, 2019. To allow for an adequate washout period, patients who were initiated on TTM before April 22, 2019 will be in the "before" group and patients initiated on TTM on or after June 1, 2019 will be in the "after" group. Patients will be identified based on electronic medical records search of order sets utilized in TTM and confirmed with manual chart review. Statistical analysis will be performed as detailed below.

Inclusion Criteria:

• Age > 18 years
• Diagnosis of cardiac arrest
• Initiation of TTM via Arctic Sun® device

Exclusion Criteria:

• Initiation of TTM > 12 hours after cardiac arrest
• Receiving NMBs for an indication other than TTM
• Early termination of TTM (less than 24 hours)

We plan to conduct the retrospective chart review of all patients identified during the study period (from June 1, 2017 to May 31, 2021) that meet the inclusion and exclusion criteria.