carDIo-ttranSSfOrm nucLEar Imaging Study

carDIo-ttranSSfOrm nucLEar Imaging Study

The investigators will evaluate the change in myocardial uptake of 99m-technetium pyrophosphate (Tc-99m PYP) tracer on serial planar and SPECT imaging in patients enrolled in the CARDIO-TTRansform clinical trial (NCT04136171).

This is a multicenter trial of 80 subjects enrolled in the CARDIO-TTRansform randomized clinical trial (NCT04136171) who will undergo baseline and follow up Tc-99m PYP to assess for the change in myocardial uptake of the tracer.

Inclusion Criteria:

• Patients who were screened and eligible to be enrolled or have been already enrolled in the CARDIO-TTRansform randomized clinical trial (NCT04136171) and have a baseline 99m-technetium pyrophosphate planar and SPECT imaging done within 12 months prior to screening for CARDIO-TTRansform.
• Patients have to meet the inclusion and exclusion criteria of CARDIO-TTRansform trial to be enrolled.
• Patient willing to consent for the study and undergo the study procedures.

Exclusion Criteria:

• None