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According to the existing literature reports, the misdiagnosis rate of CT is as high as 22% - 68%. Thymic cyst and lymphoma are usually misdiagnosed as thymoma, resulting in many unnecessary operations; In addition, traditional imaging technologies can also cause a missed diagnosis rate of about 7%, which is common in the missed diagnosis of asymptomatic thymoma, which delays the opportunity of treatment. Therefore, in order to accurately treat thymic tumors, the existing diagnostic methods of thymic tumors need to be further optimized.
Our previous retrospective study found that the level of IL-8 + initial T cells can well distinguish thymoma from other types of anterior mediastinal tumors, and the sensitivity and specificity are close to 95%.
This study is a prospective, multicenter diagnostic accuracy study. 310 patients with anterior mediastinal space occupying lesions who meet the enrollment conditions are planned to be recruited continuously. 5ml peripheral venous blood of the patients is taken before surgery or puncture biopsy and sent to the laboratory for blind detection of IL-8 + initial T cell level; Then the patient underwent anterior mediastinal tumor surgery or biopsy to obtain pathological results (gold standard for diagnosis). After the pathological results were confirmed, all cases were divided into thymoma group and non thymoma group. The sensitivity and specificity of IL-8 + initial T cells in the diagnosis of thymoma and the cutoff value of thymoma were calculated.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| level of IL-8+ initial T cells | Diagnostic Test | 5ml peripheral venous blood was taken before surgery or biopsy, and the levels of initial T cell with IL-8+, PLXND1+, PTK7+ or CR2+ were detected and recorded within 6 hours, respectively. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The sensitivity of levels of IL-8+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year | |
| The specificity of levels of IL-8+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year | |
| The cutoff value of levels of IL-8+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| The sensitivity of levels of PLXND1+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year | |
| The specificity of levels of PLXND1+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
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Inclusion Criteria:
Exclusion Criteria:
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the patients who are clinically diagnosed with thymic masses.
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| Name | Affiliation | Role |
|---|---|---|
| Jianyong Ding | Zhongshan Hospital Attached To Fudan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 180 Fenglin Road | Shanghai | 200032 | China |
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| ID | Term |
|---|---|
| D013945 | Thymoma |
| ID | Term |
|---|---|
| D018193 | Neoplasms, Complex and Mixed |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D013953 | Thymus Neoplasms |
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5ml peripheral venous blood was taken before surgery or biopsy, and the levels of initial T cell with IL-8+, PLXND1+, PTK7+ or CR2+ were detected and recorded within 6 hours, respectively.
| The sensitivity of levels of PTK7+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The specificity of levels of PTK7+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The sensitivity of levels of CR2+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The specificity of levels of CR2+ initial T cells in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The sensitivity of enhanced CT/MRI in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The specificity of enhanced CT/MRI in the diagnosis of thymoma | Through study completion, an average of 2 year |
| The sensitivity of levels of IL-8+, PLXND1+, PTK7+ and/or CR2+ initial T cells combined with enhanced CT/MRI in the diagnosis of thymoma | Through study completion, an average of 2 year |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |