This protocol is a case-control, multicenter, diagnostic study to collect blood samples to support the development of blood-based screening tests for multiple cancers.

Key Inclusion Criteria:

• Age at least 30 years

• Able and willing to provide blood samples per protocol

• Able to comprehend and willing to sign and date the informed consent documents

• Participants must meet one of the following:

  • Diagnosed with a single primary cancer that has not yet been treated
  • No evidence or treatment of any cancer for at least 5 years prior to enrollment

Key Exclusion Criteria:

• A medical condition which, in the opinion of the investigator, should preclude enrollment in the study
• Known to be pregnant
• Any therapy for cancer, including surgery, chemotherapy, immunotherapy, and/or radiation therapy in the 5 years preceding enrollment
• Participated or currently participating in a clinical research study in which an experimental medication has been administered in the last 30 days
• Participated in or currently participating in another Freenome clinical study
• For the control cohort: Any previous cancer diagnosis in the 5 years preceding enrollment, or recurrence of the same primary cancer within any timeframe; or concurrent diagnosis of multiple primary cancers within any timeframe
• For the cancer cohorts: Any previous cancer diagnosis in the 5 years preceding enrollment, apart from the current cancer diagnosis; OR recurrence of the same primary cancer within any timeframe; OR concurrent diagnosis of multiple primary cancers within any timeframe

Adults 30+ who have been newly diagnosed (treatment-naive) with cancer and Adults 30+ without cancer