Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.

Evaluation Of Levels Of Pigment Epithelium-Derived Factor (PEDF) In Patients With Psoriasis.

Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.

Inclusion Criteria:

Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group.

Exclusion Criteria:

• Pregnancy.
• Patients with other inflammatory skin disorders.
• Patients on antioxidants or anti-inflammatory drugs.
• Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study.
• Patients on systemic retinoids (Acitretin).
• Obesity: body mass index (BMI ) > 30.
• Malignancies e.g squamous cell carcinoma.
• Viral warts.
• Diabetes.
• Hypertension.