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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01HD102337-04 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
| Wayne State University | OTHER |
| University of Washington | OTHER |
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The researchers will use technology-assisted ambulatory assessment techniques to examine cognitive dysfunction in people with Multiple Sclerosis (MS).
The researchers will determine if ambulatory assessments are sensitive to subtle declines in cognitive functioning. They will also explore the impact of modifiable factors, such as sleep, physical activity, mood, and somatic symptoms on cognitive function. These efforts will uncover behavioral and medical intervention methods. Finally, they will explore whether variability in cognitive functioning predicts short- and long-term changes in other patient-centered functional domains, social participation and physical functioning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants | Participants with Multiple Sclerosis who meet eligibility criteria. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive Function - Ambulatory measurement via Dot Memory Test | Reported in terms of Euclidian distance/error Cognition Covariates may include: age, sex, disease duration, Multiple Sclerosis (MS) subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). | Baseline up to year 2 |
| Change in Cognitive Function - Ambulatory measurement via Symbol Search Test | Reported in Reaction Time (milliseconds) Cognition Covariates may include: age, sex, disease duration, Multiple Sclerosis (MS) subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). | Baseline up to year 2 |
| Change in Cognitive Function - clinic-based neurocognitive measurement via NIH Toolbox Cognitive Battery | Test Battery reported in T-scores. Covariates may include: age, sex, disease duration, MS subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). | Baseline up to year 2 |
| Change in Cognitive Function - clinic-based neurocognitive measurement via Symbol Digit Modalities test | Covariates may include: age, sex, disease duration, MS subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). The score is the number of correct answers in 90 seconds. Higher scores indicates better attention and processing speed. | Baseline up to year 2 |
| Change in Cognitive Function - clinic-based neurocognitive measurement via Paced Auditory Serial Addition Test | Covariates may include: age, sex, disease duration, MS subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). The score range is 0-60 and higher numbers indicate better sustained attention, speed of information processing, and working memory. |
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Inclusion Criteria:
Exclusion Criteria:
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Participants include a diverse sample of patients with MS
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| Name | Affiliation | Role |
|---|---|---|
| Anna Kratz | University of Michigan | Principal Investigator |
| Nora Fritz | Wayne State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | United States | ||
| Wayne State University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39325510 | Derived | Kratz AL, Ehde DM, Alschuler KN, Pickup K, Ginell K, Fritz NE. Optimizing Detection and Prediction of Cognitive Function in Multiple Sclerosis With Ambulatory Cognitive Tests: Protocol for the Longitudinal Observational CogDetect-MS Study. JMIR Res Protoc. 2024 Sep 26;13:e59876. doi: 10.2196/59876. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Baseline up to year 2 |
| Change in Cognitive Function - clinic-based neurocognitive measurement via Rey Auditory Verbal Learning Test | Covariates may include: age, sex, disease duration, MS subtype (relapsing vs. progressive subtypes combined), personality variables, and cognitive reserve (education plus scores on test of vocabulary). The scores from the test represent the total immediate recall (over 5 learning trials), delayed recall, and recognition. Higher scores indicate better verbal learning and memory. | Baseline up to year 2 |
| Detroit |
| Michigan |
| 48202 |
| United States |
| University of Washington | Seattle | Washington | 98195 | United States |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |