Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

The purpose of this study is to compare clinical outcomes after mechanical debridement of at sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after treatment with or without aPDT

Inclusion Criteria:

• One pocket on each side of the mouth (split design)
• Single rooted tooth
• Pocket depths measured greater than 4mm with bleeding on probing
• Horizontal bone loss
• No furcation involvement

Exclusion Criteria:

• current heavy smokers (>10 cigarettes/day)
• have uncontrolled diabetes (HbA1c ≥ 6.5%)
• other uncontrolled systemic diseases that may comprise healing, such as Vitamin C deficiency, any neutrophil deficiencies, immunodeficiency syndromes, or leukemia
• taking antibiotics within 3 months before the procedure
• vertical bone defects that requires surgical regenerative treatment.
• Pregnancy