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| Name | Class |
|---|---|
| Silpakorn University | OTHER |
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Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection, causative pathogens resulting in topical 2% mupirocin ointments period compare with 0.1% gentamicin cream period. Rate of catheter removal, time to first peritoneal dialysis-related infection after apply gentamicin cream.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mupirocin and Gentamicin | Experimental | 2% mupirocin ointments apply at exit-site once daily after wound cleaning before recruit in the study then use 0.1% gentamicin cream apply at exit-site once daily after wound cleaning after entry to the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mupirocin | Drug | Apply mupirocin ointments for prevention of peritoneal dialysis-related infection between 1 January 2021 to 31 December 2021 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Exit-site infection in mupirocin compared with gentamicin group | Exit-site infection diagnosis by physician. Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group. | All exit-site infection episodes occurred last year in mupirocin group and all exit-site infection episodes have occurred after apply 0.1% grntamicin cream for 1 year. |
| Rate of Infectious peritonitis in mupirocin compared with gentamicin group | Infectious peritonitis diagnosis by physicians. Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group | All infectious peritonitis episodes occurred last year in mupirocin group and all infectious peritonitis episodes have occurred after apply 0.1% grntamicin cream for 1 year. |
| Measure | Description | Time Frame |
|---|---|---|
| Number and percentage Causative pathogens of Exit-site infection in mupirocin compared with gentamicin group | Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group | All pathogenic organisms of exit-site infection episodes occurred last year in mupirocin group and all pathogenic organisms of exit-site infection episodes have occurred after apply 0.1% grntamicin cream for 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ittaprach Yimsuk, PharmD | Contact | 097-237-4797 | ittaprach.y@gmail.com | |
| Pamila Tasanavipas, MD | Contact | 081-344-2383 | pa_tass@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ittaprach Yimsuk, PharmD | College of Pharmacy, Rangsit university | Study Chair |
| Pamila Tasanavipas, MD | Phramongkutklao hospital and College of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Phramongkutklao Hospital | Recruiting | Ratchathewi | Bangkok | 10400 | Thailand |
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| ID | Term |
|---|---|
| D016712 | Mupirocin |
| D005839 | Gentamicins |
| ID | Term |
|---|---|
| D004852 | Epoxy Compounds |
| D004988 | Ethers, Cyclic |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
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Single group: topical mupirocin ointment retrospective period compare with gentamicin prospective period
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| Gentamicin | Drug | Apply gentamicin creams for prevention of peritoneal dialysis-related infection for 1 year start after 1 January 2022 |
|
|
| Number and percentage Causative pathogens of Infectious peritonitis in mupirocin compared with gentamicin group | Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group | All pathogenic organisms of infectious peritonitis episodes occurred last year in mupirocin group and all pathogenic organisms of infectious peritonitis episodes have occurred after apply 0.1% grntamicin cream for 1 year. |
| Percentage of catheter removal due to peritoneal dialysis-related infection | Prospective data collection from patient's medical records in gentamicin group | Retrospective period at least 1 year before recruit to the study, Prospective period at least 1 year after entry to the study. |
| Time to first peritoneal dialysis-related infection after gentamicin application | Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group. Peritoneal-related infection diagnosis by physicians. Prospective data collection from patient's medical records in gentamicin group | Prospective period at least 1 year after entry to the study. |
| Drug susceptibility of causative pathogens of peritoneal dialysis-related infection | Drug susceptibility test by broth micro-dilution and E-test. Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group | Retrospective period at least 1 year before recruit to the study, Prospective period at least 1 year after entry to the study. |
| Daraporn Rungprai, BCP |
| Faculty of Pharmacy, Silpakorn University |
| Study Director |
| Wichai Santimaleeworagun, BCP | Faculty of Pharmacy, Silpakorn University | Study Director |
| Kulthida Chaijumroen, B.N.S. | Phramongkutklao hospital and College of Medicine | Principal Investigator |
| D011714 |
| Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |