Low accrual rate

The purpose of this open, mono center trial is to assess the impact of the use of an amniotic membrane on the healing of a keratitis resistant to medical treatment.

Inclusion Criteria:

• Male or female; age between 18 and 65 years.
• Patient with non-infectious keratitis resistant to medical treatment for more than 15 days or recurrent after healing treatment.
• Patient with quantitative and qualitative score for inflammatory ocular signs > 20.
• Patient with Oxford grade > 2.
• Informed and consenting patient with a relative or friend available to instill eye drops if necessary.
• Patient affiliated to a social security system or beneficiary of such a system.

Exclusion Criteria:

• Patient with active infectious keratitis (bacterial, parasitic or viral).
• Patient with allergy to Oxybuprocaine or Tetracaine eye drops, to ester type local anesthetics and to fluorescein.
• Current contact lens wear, including scleral lenses.
• NSAID eye drops and any drops containing preservatives.
• Antibiotic, anti-viral, anti-parasitic eye drops.
• Patient with identified causes for the keratitis for which discontinuation of medical treatment beneficial.
• Ocular surgery in the 3 months preceding the inclusion in the study.
• Monophtalmic patient.
• Person deprived of liberty by a judicial or administrative decision.
• Adult subjected to a legal protection measure or unable to express his/her consent.