NGS vs Culture Outcomes for Treatment of PJI

Randomized Controlled Trial Investigating the Use of Next-generation Sequencing in Directing the Antimicrobial Treatment of Periprosthetic Joint Infection

This multicenter, randomized controlled trial will compare the use of NGS and traditional culture in directing antimicrobial treatment for patients with periprosthetic joint infection.

Inclusion Criteria:

• Adults (age > 18 years)
• Undergoing single stage revision or 1st stage resection arthroplasty/spacer placement for PJI (ICM-positive) of the hip or knee
• Written informed consent

Exclusion Criteria:

• Ongoing participation in another clinical trial
• Megaprosthesis