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This study will determine if airway resistance to airflow and pressure, measured by Impulse Oscillometry, is impacted in subjects with vocal cord disorders and whether these measurements are different when compared to subjects with asthma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects with a diagnosis of vocal cord dysfunction | Subjects with a confirmed or suspected diagnosis of vocal cord dysfunction (also called inducible laryngeal obstruction). Some subjects will have concomitant diagnosis of asthma. |
| |
| Subjects with diagnosis of asthma | Subjects with physician-diagnosed asthma. Some subjects will have concomitant diagnosis of vocal cord dysfunction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Impulse Oscillometer | Device | The tremoFlo C-100 Airwave Oscillometry System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean respiratory system impedance | The oscillometer will collect an airway impedance measurement which is made up of multiple variables. | Single measurement, approximately day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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Up to one hundred (100) human subjects will be recruited from the following University of Rochester locations: Mary Parkes Center for Asthma, Allergy, and Pulmonary Care, the Pulmonary Clinic at Strong Memorial Hospital, and The Voice Center, an Otolaryngology Clinic at Clinton Woods.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mary Parkes Asthma and Allergy Center | Rochester | New York | 14623 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39631550 | Derived | Donohue P, Connolly M, D'Alfonso M, Jackson G, Grasso LC, Cai X, O'Connell Ferster AP, Schneider GT, Khurana S, Georas SN. Peripheral airways dysfunction measured by oscillometry differentiates asthma from inducible laryngeal obstruction. Respir Med. 2025 Jan;236:107905. doi: 10.1016/j.rmed.2024.107905. Epub 2024 Dec 3. |
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|
| ID | Term |
|---|---|
| D009058 | Mouth Breathing |
| D012131 | Respiratory Insufficiency |
| D064706 | Vocal Cord Dysfunction |
| D001249 | Asthma |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007818 | Laryngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D001982 | Bronchial Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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