Placental Perfusion in the Entire Placenta and With Sonobiopsy by Ultrasound

Correlation Between the Placental Perfusion Measured in the Entire Placenta and With Sonobiopsy

In this study is tested the validity of placental vascular indices obtained from placenta ultrasonographic sphere biopsy and entire placenta investigation.

Although, to this date, there have been a number of human placental studies that concerned the evaluation of placental 3 dimensional power Doppler vascularization with the use of VOCAL technique, but there was no one in which placental vasculature has been compared between the sonobiopsy and whole placental volume.

Exclusion criteria:

• multiple pregnancy,
• abnormal (> 3mm) nuchal translucency from 11+0 to 13+6 weeks of gestation,
• the fetal or neonatal structural or chromosomal anomaly,
• inadequate localization of the placenta (placenta praevia),
• self-reported drugs, alcohol, caffeine or nicotine abuse,
• exposed to circulatory medication (oxerutins, calcium dobesilate)
• or not signing the consent form.
• If the mother suffer from er systemic disease (e.g. diabetes, autoimmune disease, vasculitis, haemophilia, thrombophilia, HIV infection, etc)

Inclusion clriteria:

• single pregnancy
• healthy pregnant women
• no anatomical alteration of fetus
• no genetical abnormality of fetus