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The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative stress parameters in healthy humans following a high intensity physical workout.
The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative stress parameters in healthy humans following a high intensity physical workout. The choice of food will mainly be based on the food groups from the Empirical Dietary Inflammatory Index. For that purpose, forty-two healthy volunteers will be recruited to perform several interventions in order to assess the impact of different nutrient groups or single- foods on oxidative and inflammatory markers. They will be divided into two groups (beverage consumption, n=20 & plantbased foods, n=22). The intense physical activity serves to induce a physiological stress response in the body, known to be accompanied by an increase in oxidative and inflammatory stress parameters. The idea is that anti- inflammatory or antioxidant nutrients could potentially attenuate this stress response in dependence on their anti- inflammatory or antioxidant potential. The operability of this concept has already been tested. The main benefit of this approach is to get a deeper insight into short term effects of single foods or beverages on inflammatory and prooxidative processes in humans by using short term intense physical activity as a stress model. One major practical aspect of this approach is to assess dietary components with respect to their pro- or anti-inflammatory-/oxidative stress potential regarding e.g. non-communicable diseases such as type 2 diabetes, coronary heart disease or the metabolic syndrome. Furthermore, it could help to reduce inflammation or oxidative stress during or following high intense physical exercise in order to reduce the stress response during training or competition in order to enhance regeneration and to foster the training gain in sports.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Impact of GT, coffee, OJ, PGJ, milk, SSB on exercise induced oxidative stress&inflammation | Experimental | single consumption of one cup of green tea (GT), coffee, orange juice (OJ), pomegranate juice (PGJ), milk and sugar sweetened beverage (SSB) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects |
|
| Impact of choc, bcc, fl-oil, blueb., r&w bread on exercise induced oxidative stress&inflammation | Experimental | single consumption of one proportion of dark chocolate (choc), broccoli (bcc), flaxseed oil, blueberries, white bread and whole grain bread (r = refined & w = whole grain) 2 hours prior to a 30-min-HIIT resistance circuit exercise in healthy human subjects |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nutrition | Other | acute single dose nutrition intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| ROS change | ROS (change from baseline = after overnight fasting to post exercise (=after 2.5 hours) | change from baseline to 2.5 hours |
| IL-6 change | IL-6 (change from baseline = after overnight fasting to post exercise (=after 2.5 hours) | change from baseline to 2.5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| estradiol | 17-beta-estradiol | baseline |
| DNA damage (comet assay | comet assay - wholeblood | change from baseline to 2.5 hours |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Markus Gassner, MSc | University Assistant | Principal Investigator |
| Daniel König, Univ Prof | Professor of sports nutrition | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vienna | Vienna | Austria | 1070 | Austria |
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| ID | Term |
|---|---|
| D009752 | Nutritional Status |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D006304 | Health Status |
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acute consumption of anti- and pro- inflammatory foods (n=22) and beverages (n=20) 2 hour prior to intense physical activity in healthy female subjects (in total 42 subjects)
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| MDA change | MDA (change from baseline = after overnight fasting to post exercise (=after 2.5 hours) | change from baseline to 2.5 hours |
| hs-CRP change | hs-CRP (change from baseline = after overnight fasting to post exercise (=after 2.5 hours) | change from baseline to 2.5 hours |
| FRAP | Ferric Reducing Antioxidant Power Assay | change from baseline to 2.5 hours |
| Polyphenol Content | Polyphenol Content Plasma | change from baseline to 2.5 hours |
| Lipidomics | oxLDL | change from baseline to 2.5 hours |
| Protein Carbonyls | Protein Carbonyl Assay | change from baseline to 2.5 hours |
| D003710 | Demography |
| D011154 | Population Characteristics |