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The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| S-ketamine | Experimental |
| |
| Sufentanil | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| S-ketamine | Drug | S-ketamine 0.5mg/kg for induction and 0.2mg/kg/h for maintenance |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The probability of numerical rating scale (NRS) score being less than or equal to 3 when leaving the Postanesthesia Care Unit (PACU) | The probability of numerical rating scale (NRS) score being less than or equal to 3 when leaving the Postanesthesia Care Unit (PACU) | 1 day of the surgery |
| Measure | Description | Time Frame |
|---|---|---|
| The area under the curve (AUC) of mean arterial pressure (MAP) within 10 minutes after induction is lower than the baseline mean arterial pressure (MAP 3 minutes before induction). | The area under the curve (AUC) of mean arterial pressure (MAP) within 10 minutes after induction is lower than the baseline mean arterial pressure (MAP 3 minutes before induction). | From the date of the beginning of anesthesia until the date of the end of anesthesia, assessed up to 2 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ling Zhou | Contact | +86 15895918786 | lingzhou531@foxmail.com | |
| Chun Yang | Contact | +8618260062666 | chunyang@njmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Nanjing Medical University | Recruiting | Nanjing | Jiangsu | 210029 | China |
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| ID | Term |
|---|---|
| C000629870 | Esketamine |
| D017409 | Sufentanil |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Sufentanil |
| Drug |
Sufentanil 0.2-0.3μg/kg for induction and remifentanil 0.05-0.15μg/kg/min for maintenance |
|
| herat rate and blood pressure during the surgery every 5 minutes | From the date of the beginning of anesthesia until the date of the end of anesthesia, assessed up to 2 days |
| Total dosage of anesthesia drug | From the date of the beginning of anesthesia until the date of the end of anesthesia, assessed up to 2 days |
| Total dosage of vasoactive agents | From the date of the beginning of anesthesia until the date of the end of anesthesia, assessed up to 2 days |
| The duration of surgery | From the date of the beginning of surgery until the date of the end of surgery, assessed up to 2 days |
| Time until awake | From the end of anesthesia until awake, assessed up to 2 days |
| Time to removal of tracheal intubation | From the end of anesthesia until the time of removal of tracheal intubation, assessed up to 2 days |
| Incidence of postoperative nausea and vomiting | 48 hours after the surgery |
| Incidence of postoperative delirium | 48 hours after the surgery |
| Incidence of hypoxemia | 48 hours after the surgery |
| Postoperative first analgesia demand | The first time that the patient ask for analgesia | From the end of anesthesia until the date of first demand of analgesia drugs, assessed up to 1 week |
| numerical rating scale (NRS) pain score | 24 hours and 48 hours after the surgery |
| Postoperative hospital stay | From the date of the surgery until the date being discharged from hospital, up to 1 month |