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use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and compare them with age-matched controls.
A prospective case-control clinical study. The study subjects were divided into 3 groups, group 1 of inactive thyroid patients, group 2 of active thyroid patients, and group 3 of healthy controls. The AS-OCT was used to measure lower tear meniscus parameters (tear meniscus height (TMH), tear meniscus depth (TMD), and tear meniscus area (TMA)), total CT and epithelial thickness
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 | 70 eyes of 35 patients of thyroid inactive disease |
| |
| Group 2 | 70 eyes of 35 patients of thyroid active disease |
| |
| Group 3 | Healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AS-OCT | Diagnostic Test | Optical Coherence Tomography (OCT) creates detailed cross-sectional images of the anterior and posterior segments using low coherence interferometry. OCT is a noninvasive, real-time method for evaluating the tear meniscus, total corneal thickness (CT), and corneal epithelial thickness |
| Measure | Description | Time Frame |
|---|---|---|
| Tear Meniscus Height | represented by a line joining the points corresponding to the upper corneo-meniscus junction to the lower eyelid-meniscus junction | through study completion, an average of 6 months |
| Tear Meniscus Depth (TMD): | represented as the distance between the center of the upper boundary of the tear meniscus and the point at the bottom boundary where the cornea meets the eyelid | through study completion, an average of 6 months |
| Tear Meniscus Area (TMA) | triangular area formed by the corneal anterior boundary, anterior boundary of the lower eyelid and anterior borderline of the tear meniscus | through study completion, an average of 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients were divided into 3 groups. Group 1 included 70 eyes of 35 patients of thyroid inactive disease, group 2 included 70 eyes of 35 patients of thyroid active disease, and group 3 included 70 eyes of 35 healthy controls
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| Name | Affiliation | Role |
|---|---|---|
| mohamed Mahmoud | Minia faculty of medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Minia Faculty of medicine | Minya | Egypt | ||||
| Minia University hospital |
IPD will not to be shared
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| ID | Term |
|---|---|
| D049970 | Graves Ophthalmopathy |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D006111 | Graves Disease |
| D005094 | Exophthalmos |
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|
| Minya |
| Egypt |
| D009916 |
| Orbital Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006042 | Goiter |
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D006980 | Hyperthyroidism |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |