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Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.
Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control cohort | lung-healthy volunteers get a EIT measurement | ||
| Case cohort | Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| additional EIT Measurement | Diagnostic Test | Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between tomography and electroimpedance tomography | The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography. | until May 2022 |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between lung function testing and electroimpedance tomography | until May 2022 |
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Inclusion Criteria:
Exclusion Criteria:
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All patients presenting to the post-COVID-19 outpatient clinic are screened.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jan-Christoph Lewejohann, Dr. | Contact | +49 3641 9 32 20 13 | jan-christoph.lewejohann@med.uni-jena.de | |
| Phillip A. Reuken, Dr. | Contact | +49 3641 9 32 4504 | Philipp.reuken@med.uni-jena.de |
| Name | Affiliation | Role |
|---|---|---|
| Phillip A Reuken, Dr. | Jena University Hospital, Klinik für Innere Medizin IV | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Notfallmedizin | Jena | Thuringia | 07747 | Germany |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 18, 2021 | Feb 8, 2022 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D000094024 | Post-Acute COVID-19 Syndrome |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
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| D007239 |
| Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |