Comparing the Efficacy of Visible Light-Ultraviolet A1 Light Versus Narrowband-Ultraviolet B on Generalized Vitiligo

Comparing the Efficacy of VL-UVA1 Versus NB-UVB on Inducing Repigmentation in Subjects With Generalized Vitiligo

As part of this study, you may have a procedure called phototherapy which involves either VL-UVA or NB-UVB irradiation. NB-UVB phototherapy is not experimental in vitiligo, but use of VL-UVA1 phototherapy in vitiligo is.

The purpose of this pilot study is to determine whether VL-UVA1 or NB-UVB phototherapy more efficiently induces repigmentation in patients with generalized vitiligo.

Inclusion Criteria:

• Subjects ≥ 18 years of age with a diagnosis of generalized vitiligo
• Subjects on a stable topical/oral regimen for the past 3 months and continuing on a stable regimen
• Subjects able to understand the requirements of the study
• Subjects able and willing to sign informed consent

Exclusion Criteria:

• Subjects on photosensitizing medications
• Subjects receiving any concurrent phototherapy
• Subjects who plan to use tanning parlors or expose themselves to excess sunlight
• Subjects with known photosensitivity disorder
• Subjects with apparent phototoxicity
• Subjects with unstable vitiligo
• Subjects currently using bleaching agents
• Subjects who are pregnant, lactating, or planning on becoming pregnant
• Subjects who in the opinion of the investigator/sub-investigator, are not appropriate candidates for this study