Nephrolithiasis is a disease caused by the formation of kidney stones in the urinary tract which can then partially or completely obstruct the latter causing an extremely sharp pain called renal colic. In industrialized countries, it affects 10 to 20% of the population, and is the most common kidney disease.The primary objective of this study is to identify the clinical, biological, genetic, molecular and environmental determinants predictive of recurrence of renal lithiasis.

The study follow-up visit schedule corresponds to the visits usually scheduled as part of patient care: 1 year from the inclusion visit (A1), 3 years (A3) then 5 years (A5). Samples for research (additional volume of blood, urine) will be taken by a registered nurse along with the routine check-up samples.Samples intended for research will be sent by staff to the Biobanque de Picardie (CHU Amiens-Picardie) for processing and conservation.

Inclusion Criteria:

• Adults (≥18 years old), male or female ,
• Persons able to understand and object to the information provided (at the discretion of the investigator)
• Patient affiliated to social security
• Patient agreeing to sign the informed consent form
• patient having presented at least one renal colic attack before inclusion

Exclusion Criteria:

• Pregnant or breastfeeding woman.
• Persons deprived of liberty,
• Adults under legal protection guardianship, or curators or unable to express their consent.
• Patient refusing to participate in the study
• Patient in an emergency situation