The study's objective is to test the hypothesis that immune system activation and subsequent systemic inflammation can be detected through continuously tracking multiple bio signals including physiologic variables (ECG, skin temperature and their derivatives) and behavioral variables (activity and sleep from accelerometers) collected during routine activities of daily living using wearable biosensors. In the sub-study, the objective is to explore the association between these objectively measured physiologic changes and vaccine-induced humoral and T-cell responses.

Inclusion Criteria:

• Is 18 years of age or older.
• Is able to speak and read English.
• Plan to receive either the Moderna or Pfizer vaccine (mRNA vaccine).
• No known prior COVID-19 infection.

Exclusion Criteria:

• Known allergy to the adhesive used on the VitalPatch.

Adults that plan to receive COVID-19 vaccine.