The main objective of the present study will be to establish whether a slow (within 160 days) or a rapid (within 60 days) withdrawal schedule of antiepileptic monotherapy influence relapse rate in adult patients with epilepsy, who have been seizure free for at least 2 years. Secondary objectives will be to establish the compliance rates with these two schedules and the differences in terms of severity of relapses, based on the occurrence of status epilepticus, seizure-related injuries and death.

Inclusion Criteria:

• diagnosis of focal or generalized epilepsy (according to International League Against Epilepsy 1989 criteria)
• age at epilepsy onset of 16 years or older
• seizure freedom for at least 2 years
• treatment with one of the antiepilepsy drugs currently available for monotherapy in Italy: carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid zonisamide)
• adherence to the protocol and visit schedules.

Exclusion Criteria:

• inability to understand the aims or modalities of the study;
• current pregnancy or plans to become pregnant during withdrawal period;
• history of seizure relapse after discontinuation of treatment;
• history of psychogenic non-epileptic seizures (PNES);
• history of status epilepticus