• Diagnosis of infection based on elevated serum markers of infection (ESR, CRP), discharging sinus, preoperative radiographs suggestive of bone infection and radiological findings . [6]
• infected nonunion mean the bone has previous fracture , the bone not healed may be one of the reasons it didn't heal because there is sub-acute infection , there is low grade colonization into the bone or around the wound preventing the bone from healing , it different from infected fracture which occur fairly acutely. [6, 7]
• Infected nonunion treated with systemic antibiotics alone, without using local antibiotic delivery systems associated with higher recurrence and reoperation rates. [7]
• This led to the development and use of medical-grade calcium sulfate (CS), CS facilitates osseous healing in an osteoconductive fashion by filling the bone void and preventing fibrous tissue

Inclusion Criteria:

• Patient at any age and of any sex with infected non united fracture of long or short bones

Exclusion Criteria:

• Presence of previous vascular injury or pathological fracture
• Refusal to participate
• Inability to provide informed consent
• Allergy or sensitivity to vancomycin or tobramycin
• Patient with impaired renal function
• Patient with hypercalcemia