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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-A00216-37 | Other Identifier | ID-RCB |
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Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system (NMS)), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson's disease patients | 30 parkinsonian patients scheduled for deep brain stimulation implantation surgery will be recruited |
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| Controls | 15 healthy volunteers matched in age and sex will be recruited |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| social cognition tests | Behavioral | The evaluation of social cognition will be carried out using questionnaires and a point lights computer test. During the computer test, participants have to watch several short sequences of interactions between two silhouettes and give an interpretation of the scene. Patients will be evaluated twice: one time before the surgery and a second time 1 year after surgery. Healthy volunteers will be evaluated only one time. |
| Measure | Description | Time Frame |
|---|---|---|
| Emotional resonance task score | In the emotional resonance task, patients are asked to rate the emotional valence of fifteen 3-second silent videos. These movies show emotionally connoted motor interactions between two persons, each of them being depicted by 20 white dots moving on a black background (Point Light Displays (PLD) technique). Among these 15 videos, 5 has a negative valence (making someone cry, sadness, argument, hitting someone and anger), 5 has a positive valence (joy, dancing, giving a flower, laughing and cuddling) and 5 neutral valences (sit, stand, say hello, raise your arms and saw). The Emotional resonance score in parkinsonian patients undergoing treatment (dopaminergic or deep brain stimulation) will be compared to their score without treatment (OFF Dopa or OFF stimulation). | 12 months following the inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Correlations between the emotional resonance task score and patients' quality of life self-questionnaire score (PDQ39) | PDQ39 (Parkinson's Disease Questionnaire) is a 39-item self-report questionnaire assessing Parkinsons' disease-specific health and well-being over the last month. PDQ39 provide a summary score of the impact of the illness on functioning and well-being. | 12 months following the inclusion |
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Inclusion Criteria:
For all participants:
Specific inclusion criteria for patients:
Exclusion Criteria:
For all participants:
Specific exclusion criteria for healthy volunteers
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Patients likely to participate in the study and verifying the eligibility criteria will be identified within the Neurology C department as part of their neurological follow-up before and after deep brain stimulation.
Healthy volunteers will be recruited among the spouses of the patients or via association like France Parkinson.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neurology C department, P. Wertheimer Hospital | Bron | 69677 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Quality of life self-questionnaire | Behavioral | Quality of life will be assessed using a self-administered questionnaire in the patients group only. |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |