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Retrospective study designed to evaluate outcomes in patients undergoing assisted reproduction. Some of them had thrombophilia, and part of them was treated with enoxaparin, started on the day of embryo transfer, and the other part not. Women without thrombophilia formed the control group.
A retrospective study was performed to evaluate the results in 104 patients undergoing to assisted reproduction. Women without thrombophilia were included as controls (n=20), while women with thrombophilia were either treated with 40 mg daily of enoxaparin (treated group, n=54), initiated on the day of embryo transfer, and continued to the week 36 of gestation, or did not receive this medication (untreated group, n= 30).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Women without thrombophilia, submitted to in vitro fertilization techniques | ||
| Untreated Thrombophilia | Women with laboratorial thrombophilia, submitted to in vitro fertilization techniques, without treatment with enoxaparin | ||
| Treated Thrombophilia | Women with laboratorial thrombophilia, submitted to in vitro fertilization techniques, and treated with enoxaparin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Enoxaparin | Drug | Women with thrombophilia were treated with 40 mg daily of enoxaparin (treated group), initiated on the day of embryo transfer, up to week 36 of gestation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with detectable fetal heartbeat | A transvaginal ultrasound was performed for detection of fetal heartbeat | Day 28 |
| Number of participants with detectable ongoing pregnancy | Ongoing pregnancy was detected by ultrasound at twelve weeks | Week 12 |
| Number of participants who delivered a live baby | Live birth was considered delivery that resulted in at least one live born neonate | Week 36 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with biochemical gestation detected | Serum beta-HCG detected 14 days after embryo transfer | Day 14 |
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Inclusion Criteria:
Exclusion Criteria:
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All included patients underwent in vitro fertilization (IVF) treatment with intracytoplasmic sperm injection (ICSI). Patients were initially submitted to controlled ovarian hyperstimulation under a short protocol with gonadotropins and GnRH antagonist. Women with laboratorial thrombophilia could be treated or not with enoxaparin according to her physician's decision. Women without detectable thrombophilia formed the control group.
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| Name | Affiliation | Role |
|---|---|---|
| Luciano M Pompei | Faculdade de Medicina do ABC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assistencia Materno Infantil Lambert | Santo André | São Paulo | 09041000 | Brazil |
The IPD sharing was not approved yet by our ethical committee board
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| D019851 | Thrombophilia |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D017984 | Enoxaparin |
| ID | Term |
|---|---|
| D006495 | Heparin, Low-Molecular-Weight |
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
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| D000091662 | Genital Diseases |
| D007246 | Infertility |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D002241 |
| Carbohydrates |