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| ID | Type | Description | Link |
|---|---|---|---|
| R21ES033118 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
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The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.
The aims of this feasibility study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and forced expiratory volume percent predicted, respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants' will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home Air Quality | Other | This study will assess the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, the study will assess the feasibility and usability of providing participants with a readily available indoor home air quality monitor to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). |
| Measure | Description | Time Frame |
|---|---|---|
| Episodes Per Day | Number of episodes per day that the residential VOCs exceeded 333 ppb and/or PM2.5 exceeded 15 mg/m3, as measured by the Awair home air quality monitor | Measured daily for 14 days |
| Home Spirometry Completed | Number of participants completing daily home spirometry over 14 days. | Assessed daily for 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Integration of Study Components | Participants were asked one survey item to assess if the various components of the study were well integrated. Response options ranged from 0=Strongly disagree to 4=Strongly agree. The score was multiplied by 25; scores could range from 0-100. A higher score indicated that the study components were well integrated. | 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with asthma living in the US
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| Name | Affiliation | Role |
|---|---|---|
| Barbara Polivka, PhD | Select | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barbara J Polivka | Kansas City | Kansas | 66160 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33385592 | Background | Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1378-1380.e2. doi: 10.1016/j.jaip.2020.12.038. Epub 2020 Dec 29. No abstract available. | |
| 27492540 | Background | Matulonga B, Rava M, Siroux V, Bernard A, Dumas O, Pin I, Zock JP, Nadif R, Leynaert B, Le Moual N. Women using bleach for home cleaning are at increased risk of non-allergic asthma. Respir Med. 2016 Aug;117:264-71. doi: 10.1016/j.rmed.2016.06.019. Epub 2016 Jun 25. |
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To maximize the utility of this research, and in the interests of allowing other researchers and the public to benefit from it, the investigators will make the entire protocol and deidentified dataset available to researchers.
Up to 24 months after the publication of the main study findings.
Requests for IPD will be reviewed by the MPIs once a formal email request is submitted for research addressable aims/questions/hypotheses. Once the request has been approved by the MPIs and IRB approval is obtained, only deidentified data relevant to the research questions will be shared for secondary analyses deemed appropriate by the MPIs.
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Participants were recruited from 5/2022 to 2/2023. Eligibility criteria included previous participation in the Global COVID-19 and Asthma Study (GCAS), willingness to be contacted for future research, high use of disinfectant/cleaning products during COVID-19 (≥5 per week), Asthma Control Test score ≤19 or ≥2 asthma exacerbations in the previous 12 months, owned a smartphone, and had Wi-Fi/wireless connection in their home. Non-US residents and non-English speakers were excluded.
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| ID | Title | Description |
|---|---|---|
| FG000 | A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults | We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults | We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Episodes Per Day | Number of episodes per day that the residential VOCs exceeded 333 ppb and/or PM2.5 exceeded 15 mg/m3, as measured by the Awair home air quality monitor | Posted | Mean | Standard Deviation | Episodes per day | Measured daily for 14 days |
|
14 days per participant
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults | We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control. |
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This was a feasibility study with a small sample thus potentially limiting generalizability.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Barbara Polivka | University of Kansas School of Nursing | 6142049915 | bpolivka@kumc.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 13, 2025 | Mar 13, 2025 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| Ecological Momentary Assessment (EMA) Surveys | Number of participants completing air quality triggered EMA surveys | 14 days |
| 22496323 | Background | Le Moual N, Varraso R, Siroux V, Dumas O, Nadif R, Pin I, Zock JP, Kauffmann F; Epidemiological Study on the Genetics and Environment of Asthma. Domestic use of cleaning sprays and asthma activity in females. Eur Respir J. 2012 Dec;40(6):1381-9. doi: 10.1183/09031936.00197611. Epub 2012 Apr 10. |
| 17585104 | Background | Zock JP, Plana E, Jarvis D, Anto JM, Kromhout H, Kennedy SM, Kunzli N, Villani S, Olivieri M, Toren K, Radon K, Sunyer J, Dahlman-Hoglund A, Norback D, Kogevinas M. The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med. 2007 Oct 15;176(8):735-41. doi: 10.1164/rccm.200612-1793OC. Epub 2007 Jun 21. |
| 32525852 | Background | Gharpure R, Hunter CM, Schnall AH, Barrett CE, Kirby AE, Kunz J, Berling K, Mercante JW, Murphy JL, Garcia-Williams AG. Knowledge and Practices Regarding Safe Household Cleaning and Disinfection for COVID-19 Prevention - United States, May 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 12;69(23):705-709. doi: 10.15585/mmwr.mm6923e2. |
| 42056445 | Derived | Huntington-Moskos L, Bimbi O, Cramer E, Eldeirawi K, Nyenhuis SM, Krueger K, Polivka B. Acceptability and usability of a brief video report-back to share individualized residential indoor air quality data. J Expo Sci Environ Epidemiol. 2026 Apr 29. doi: 10.1038/s41370-026-00908-0. Online ahead of print. |
| 35916686 | Derived | Nyenhuis S, Cramer E, Grande M, Huntington-Moskos L, Krueger K, Bimbi O, Polivka B, Eldeirawi K. Utilizing Real-time Technology to Assess the Impact of Home Environmental Exposures on Asthma Symptoms: Protocol for an Observational Pilot Study. JMIR Res Protoc. 2022 Aug 2;11(8):e39887. doi: 10.2196/39887. |
| Participants |
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| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Primary | Home Spirometry Completed | Number of participants completing daily home spirometry over 14 days. | Posted | Number | participants | Assessed daily for 14 days |
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| Secondary | Integration of Study Components | Participants were asked one survey item to assess if the various components of the study were well integrated. Response options ranged from 0=Strongly disagree to 4=Strongly agree. The score was multiplied by 25; scores could range from 0-100. A higher score indicated that the study components were well integrated. | Posted | Mean | Standard Deviation | score on a scale | 14 days |
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|
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| Secondary | Ecological Momentary Assessment (EMA) Surveys | Number of participants completing air quality triggered EMA surveys | Posted | Count of Participants | Participants | 14 days |
|
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|
| 0 |
| 40 |
| 0 |
| 40 |
| 0 |
| 40 |
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| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |