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Urological surgery patients will have their blood glucose measured before, during, and after surgery. Blood glucose will be measured using a continuous glucose monitor (CGM) device. We hypothesize the presence of a hyperglycemic state towards the end of surgery due to increased metabolic demand.
Surgical stress causes acute insulin resistance, increased circulating free-fatty acids, and reduced blood glucose uptake resulting in hyperglycemia. Intraoperative and postoperative glucose levels are typically only monitored in the diabetic or cardiac surgical patient. There is a lack of data on perioperative glucose levels in most prolonged surgeries and thus a barrier in determining the best glycemic management strategy to prevent or resolve acute insulin resistance and hyperglycemia. Obtaining blood glucose by CGM is less invasive and will avert disruption of current surgical pathways and standards of care while also producing reliable glucose measurements.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Urologic surgery patients |
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| Measure | Description | Time Frame |
|---|---|---|
| To determine the perioperative glycemic changes longitudinally in patients undergoing major urologic surgeries. | Interstitial blood glucose levels measured by Continuous Glucose Monitor (CGM) device, in mg/dL | Perioperatively up to post-operative day 4 |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the effect of perioperative insulin levels on glycemic variations in patients undergoing major urologic surgeries. | Serum insulin in uIU/mL will be measured from participant blood samples | Perioperatively up to post-operative day 4 |
| To determine the effect of perioperative insulin, C-peptide, and Free-Fatty Acid (FFA) |
| Measure | Description | Time Frame |
|---|---|---|
| To determine gastric emptying time of a carbohydrate drink. | A specialized carbohydrate beverage will be given to a subset of willing participants in order to establish a feasible interval for consumption before surgery | at least 2 days before surgery |
Inclusion Criteria:
Exclusion Criteria:
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Adults undergoing major urologic surgery at KUMC
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| Name | Affiliation | Role |
|---|---|---|
| Jill Hamilton-Reeves, PhD | University of Kansas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
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| ID | Term |
|---|---|
| D014570 | Urologic Diseases |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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whole blood and serum
C-peptide in ng/mL will be measured from participant blood samples |
| Perioperatively up to post-operative day 4 |
| To determine the effect of perioperative insulin, C-peptide, and Free-Fatty Acid (FFA) | FFA in mmol/L will be measured from participant blood samples | Perioperatively up to post-operative day 4 |