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| ID | Type | Description | Link |
|---|---|---|---|
| 270285 | Other Identifier | Health Research Authority |
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This study will compare the accuracy of a real-time Cine sequence in assessing cardiac volumetry.
This is a single-centre prospective study involving up to 570 patients with known or suspected cardiac disease referred for routine clinical cardiovascular magnetic resonance (CMR) assessment at Glenfield General Hospital, Leicester. In addition to standard multi-breath-hold steady-state free precession (SSFP) imaging (undertaken as part of the routine scan), each patient will also undergo additional imaging with a non-breath-hold multi-slice real-time cine sequence.
The primary outcome is the assessment of cardiac volumetry and function (end-diastolic volume, end-systolic volume, stroke volume, ejection fraction and myocardial mass) as measured by (1) the standard multi-breath-hold SSFP technique and (2) the non-breath-hold multi-slice real-time cine sequence. Secondary outcome measures will be (1) the time required for each scan, and (2) image quality for each scan. An additional secondary outcome will be to compare indexed cardiac volumes with those indexed according to measured body-surface area.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cardiovascular magnetic resonance | Diagnostic Test | CMR scan at 3 Tesla |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac volumetric assessment 1 | Left ventricular ejection fraction | 1 day |
| Cardiac volumetric assessment 2 | Left ventricular end-diastolic volume | 1 day |
| Cardiac volumetric assessment 3 | Left ventricular myocardial mass | 1 day |
| Cardiac volumetric assessment 4 | Right ventricular ejection fraction | 1 day |
| Cardiac volumetric assessment 5 | Right ventricular end-diastolic volume | 1 day |
| Cardiac strain assessment 1 | Left ventricular global longitudinal strain | 1 day |
| Cardiac strain assessment 2 | Left ventricular global circumferential strain | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Time | the time required for each scan under evaluation (real-time Cine and standard Cine) | 1 day |
| Image quality assessment | Image quality of each scan component, assessed visually on a 4-point score - excellent (3), good (2), moderate (1) and poor (0). |
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Inclusion Criteria:
Exclusion Criteria:
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Adults patients referred for routine cardiac MRI at Glenfield Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jayanth Arnold, BMBCh | Contact | 01162583038 | jra14@le.ac.uk | |
| Mohamed Elshibly | Contact | 01162583038 | mmme1@le.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Jayanth Arnold | University of Leicester | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Glenfield Hospital | Recruiting | Leicester | Leics | LE3 9QP | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40308862 | Derived | Elshibly M, Shergill S, Parke K, Budgeon C, England R, Grafton-Clarke C, Elshibly F, Kellman P, McCann GP, Arnold JR. Standard breath-hold versus free-breathing real-time cine cardiac MRI-a prospective randomized comparison in patients with known or suspected cardiac disease. Eur Heart J Imaging Methods Pract. 2025 Apr 25;3(1):qyaf042. doi: 10.1093/ehjimp/qyaf042. eCollection 2025 Jan. |
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no plan to share data
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| 1 day |
| Body-surface area | planimetered body-surface area | 1 day |